We have previously labeled cyclic RGD peptide c (RGDyK) with fluorine-18 through
conjugation labeling via a prosthetic 4-[18 F] fluorobenzoyl moiety and applied this [18 F] FB …

The αv integrins, which act as cell adhesion molecules, are closely involved with tumor
invasion and angiogenesis. In particular, αvβ3 integrin, which is specifically expressed on …

In vivo imaging of αvβ3 expression has important diagnostic and therapeutic applications.
Multimeric cyclic RGD peptides are capable of improving the integrin αvβ3–binding affinity …

Integrin αvβ3 plays a critical role in tumor-induced angiogenesis and metastasis and has
become a promising diagnostic indicator and therapeutic target for various solid tumors …

Brain tumors are highly angiogenesis dependent. The cell adhesion receptor integrin αvβ3
is overexpressed in glioma and activated endothelial cells and plays an important role in …

Glycosylation frequently improves the biokinetics and clearance properties of
macromolecules in vivo and could therefore be used for the design of radiopharmaceuticals …

Purpose We and others have reported that 18 F-and 64 Cu-labeled arginine–glycine–
aspartate (RGD) peptides allow positron emission tomography (PET) quantification of …

Purpose In vivo imaging of α v β 3 has important diagnostic and therapeutic applications. 18
F-Galacto-arginine–glycine–aspartic acid (RGD) has been developed for positron emission …

Abstract Purpose Various radiolabeled Arg-Gly-Asp (RGD) peptides have been previously
investigated for tumor integrin α v β 3 imaging. To further develop RGD radiotracers with …

Purpose The dimeric transmembrane integrin, α v β 3, is a well-investigated target by
different imaging modalities through suitably labeled arginine–glycine–aspartic acid (RGD) …