Repeated Piperacillin-Tazobactam Plasma Concentration Measurements in Severely Obese Versus Nonobese Critically Ill Septic Patients and the Risk of Under–and …
Objective: Obesity and critical illness modify pharmacokinetics of antibiotics, but piperacillin-
tazobactam continuous IV infusion pharmacokinetics has been poorly studied in obese …
tazobactam continuous IV infusion pharmacokinetics has been poorly studied in obese …
Population pharmacokinetics of piperacillin in nonobese, obese, and morbidly obese critically ill patients
The treatment of infections in critically ill obese and morbidly obese patients is challenging
because of the combined physiological changes that result from obesity and critical illness …
because of the combined physiological changes that result from obesity and critical illness …
Pharmacokinetic analysis of piperacillin administered with tazobactam in critically ill, morbidly obese surgical patients
AW Sturm, N Allen, KD Rafferty, DN Fish… - … : The Journal of …, 2014 - Wiley Online Library
Study Objective To evaluate the steady‐state pharmacokinetic and pharmacodynamic
parameters of piperacillin in morbidly obese, surgical intensive care patients. Design Open …
parameters of piperacillin in morbidly obese, surgical intensive care patients. Design Open …
Serum piperacillin/tazobactam pharmacokinetics in a morbidly obese individual
D Newman, MH Scheetz, OA Adeyemi… - Annals of …, 2007 - journals.sagepub.com
Objective: To report pharmacokinetic alterations and optimal dosing of piperacillin/
tazobactam in an obese patient. Case Summary: A 39-year-old morbidly obese (weight 167 …
tazobactam in an obese patient. Case Summary: A 39-year-old morbidly obese (weight 167 …
What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?
AS Alobaid, A Brinkmann, OR Frey… - Journal of …, 2016 - academic.oup.com
Objectives The objectives of this study were to determine the effects of obesity on unbound
trough concentrations and on the achievement of pharmacokinetic (PK)/pharmacodynamic …
trough concentrations and on the achievement of pharmacokinetic (PK)/pharmacodynamic …
Case-control study of drug monitoring of β-lactams in obese critically ill patients
M Hites, FS Taccone, F Wolff, F Cotton… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Severe sepsis and septic shock can alter the pharmacokinetics of broad-spectrum β-lactams
(meropenem, ceftazidime/cefepime, and piperacillin-tazobactam), resulting in inappropriate …
(meropenem, ceftazidime/cefepime, and piperacillin-tazobactam), resulting in inappropriate …
Steady-state pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese patients
SC Cheatham, MR Fleming, DP Healy… - International journal of …, 2013 - Elsevier
The study objective was to evaluate steady-state pharmacokinetics and pharmacodynamics
of piperacillin and tazobactam administered by prolonged infusion in obese patients …
of piperacillin and tazobactam administered by prolonged infusion in obese patients …
Effect of obesity on the pharmacokinetics of antimicrobials in critically ill patients: a structured review
AS Alobaid, M Hites, J Lipman, FS Taccone… - International journal of …, 2016 - Elsevier
The increased prevalence of obesity presents challenges for clinicians aiming to provide
optimised antimicrobial dosing in the intensive care unit. Obesity is likely to exacerbate the …
optimised antimicrobial dosing in the intensive care unit. Obesity is likely to exacerbate the …
Population pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese and nonobese patients
EK Chung, SC Cheatham, MR Fleming… - The Journal of …, 2015 - Wiley Online Library
The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in …
pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in …
[PDF][PDF] A pilot study on pharmacokinetic/pharmacodynamic target attainment in critically ill patients receiving piperacillin/tazobactam
J Martínková, M Malbrain, E Havel, P Šafránek… - Anestezjologia …, 2019 - termedia.pl
Background: In critically ill patients, multi-trauma and intensive therapy can influence the
pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics with time-dependent …
pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics with time-dependent …