Phosphate toxicity is a well-established phenomenon, especially in chronic kidney disease
(CKD), where hyperphosphatemia is a frequent occurrence when CKD is advanced. Many …

Hyperphosphatemia is one of the more prevalent metabolic disturbances in kidney failure.
Phosphate can be considered a uremic toxin based on the accumulation of phosphate …

Maintenance of phosphate balance is essential for life, and mammals have developed a
sophisticated system to regulate phosphate homeostasis over the course of evolution …

Hyperphosphatemia has consistently been shown to be associated with dismal outcome in a
wide variety of populations, particularly in chronic kidney disease (CKD). Compelling …

Hyperphosphatemia is considered as an independent risk factor for surrogate clinical
endpoints like vascular calcification (VC) and bone disease, or hard clinical outcomes like …

The importance of phosphate homeostasis in chronic kidney disease (CKD) has been
recognized for decades, but novel insights—which are frequently relevant to everyday …

Hyperphosphatemia is a common complication in patients with chronic kidney disease
(CKD), particularly in those requiring renal replacement therapy. The importance of …

Chronic kidney disease (CKD) is characterized by high cardiovascular morbidity/mortality,
which is linked in part to vascular calcification (VC) and endothelial dysfunction (ED) …

Convincing epidemiological data have repeatedly shown that increased phosphate levels
as well as generous phosphate intakes are associated with unfavourable outcome both in …

Phosphate is essential for proper cell function by providing the fundamentals for DNA,
cellular structure, signaling and energy production. The homeostasis of phosphate is …