In previous studies, oxidative stress damage has been solely considered to be the
mechanism of ovarian aging, and several antioxidants have been used to delay ovarian …

The ovarian system comprises vital organs in females and is of great significance for the
maintenance of reproductive potential and endocrine stability. Although complex …

Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

Melatonin (MT) is an endogenous hormone mainly synthesized by pineal cells, which has
strong endogenous effects of eliminating free radicals and resisting oxidative damages …

Melatonin is probably produced in all cells but is only secreted by the pineal gland. The
pineal secretion of melatonin is determined by the light–dark cycle, and it is only released at …

Ovarian aging is characterized by gradual declines in oocyte quantity and quality. Melatonin
is considered an anti‐aging agent due to its cytoprotective actions as an antioxidant. This …

Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

Increasing evidence shows that melatonin protected against age-related mitochondrial
oxidative damage. However, the protective effects of melatonin against ovarian aging has …

Oxidative stress has been recognized as one of the causal mediators of female infertility by
affecting the oocyte quality and early embryo development. Improving oxidative stress is …

In the field of assisted reproductive technology, female fertility preservation, particularly
ovarian tissue cryopreservation in adolescent cancer patients, has attracted much attention …