After more than 15 years of engagement in research on palliative sedation, we dare to pose
that it is among the most challenging topics in end-of-life care. The first publications on …

As patients approach the end of life, they often expe-rience a range of distressing symptoms
and concerns such as pain, delirium, and breathlessness. Although most symptoms and …

Background: Palliative sedation therapy (PST) is increasingly used in end-of-life care.
However, consensus about definitions, indications, and treatment decision making is …

Background: The European Association for Palliative Care (EAPC) acknowledges palliative
sedation as an important, broadly accepted intervention for patients with life-limiting disease …

Objective: The principal aim of this study was to identify, systematically and transparently,
clinical practice guidelines (CPGs) on palliative sedation from around the world. Methods: A …

Palliative sedation is an effective symptom control strategy for patients who suffer from
intractable symptoms at the end of life. Evidence suggests that the use of this practice varies …

Editor–We thank Schildman and colleagues for their comments regarding our study of
continuous sedation (CS) in end-of-life care. We agree that more work needs to be done in …

In 2009, the European Association for Palliative Care (EAPC) developed a framework on
palliative sedation, acknowledging this practice as an important and ethically acceptable …

In spite of aggressive palliative measures, symptom management can sometimes become
challenging at end of life. For these instances in which symptoms become refractory to …

1. Seymour J, Rietjens J, Bruinsma S, et al.; on behalf of the UNBIASED consortium. Using
continuous sedation until death for cancer patients: a qualitative interview study of …