TNF-α-induced Tim-3 expression marks the dysfunction of infiltrating natural killer cells in human esophageal cancer
Y Zheng, Y Li, J Lian, H Yang, F Li, S Zhao, Y Qi… - Journal of translational …, 2019 - Springer
Background Impairment of natural killer (NK) cell activity is an important mechanism of tumor
immunoevasion. T cell immunoglobulin domain and mucin domain-3 (Tim-3) is an activation …
immunoevasion. T cell immunoglobulin domain and mucin domain-3 (Tim-3) is an activation …
Increased Tim-3 expression in peripheral NK cells predicts a poorer prognosis and Tim-3 blockade improves NK cell-mediated cytotoxicity in human lung …
L Xu, Y Huang, L Tan, W Yu, D Chen, CC Lu… - International …, 2015 - Elsevier
T cell immunoglobulin-and mucin-domain-containing molecule-3 (Tim-3) has been shown to
play an important role in mediating NK-cell function in human diseases. However, the …
play an important role in mediating NK-cell function in human diseases. However, the …
The clinical significance of abnormal Tim-3 expression on NK cells from patients with gastric cancer
Z Wang, J Zhu, H Gu, Y Yuan, B Zhang… - Immunological …, 2015 - Taylor & Francis
Aim: To investigate the clinical significance of Tim-3 (T-cell immunoglobulin-and mucin-
domain-containing molecule 3) expression in natural killer (NK) cells from patients with …
domain-containing molecule 3) expression in natural killer (NK) cells from patients with …
Upregulation of T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) in monocytes/macrophages associates with gastric cancer progression
Z Wang, N Yin, Z Zhang, Y Zhang… - Immunological …, 2017 - Taylor & Francis
ABSTRACT T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) is an important
immune regulatory molecule in cancer immune system. However, expression and function of …
immune regulatory molecule in cancer immune system. However, expression and function of …
TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression
X Gao, Y Zhu, G Li, H Huang, G Zhang, F Wang, J Sun… - PloS one, 2012 - journals.plos.org
Background T cell immunoglobulin-3 (TIM-3) has been established as a negative regulatory
molecule and plays a critical role in immune tolerance. TIM-3 is upregulated in exhausted …
molecule and plays a critical role in immune tolerance. TIM-3 is upregulated in exhausted …
Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-κB/IL-6/STAT3 axis
T-cell immunoglobulin and mucin-domain containing-3 (Tim-3), mediating immune
exhaustion in tumor microenvironment, has become a promising target for tumor therapy …
exhaustion in tumor microenvironment, has become a promising target for tumor therapy …
TIM-3 promotes the metastasis of esophageal squamous cell carcinoma by targeting epithelial-mesenchymal transition via the Akt/GSK-3β/Snail signaling pathway
B Shan, H Man, J Liu, L Wang, T Zhu… - Oncology …, 2016 - spandidos-publications.com
T-cell immunoglobulin and mucin domain-containing protein-3 (TIM-3), a negative regulator
of antitumor immune response, has been demonstrated to be involved in the onset and …
of antitumor immune response, has been demonstrated to be involved in the onset and …
[HTML][HTML] Comprehensive analysis of the expression, relationship to immune infiltration and prognosis of TIM-1 in cancer
X Kong, M Fu, X Niu, H Jiang - Frontiers in Oncology, 2020 - frontiersin.org
TIM-1 is a critical gene that regulates T-helper cell development. However, little research
has revealed the distribution, prognosis, and immune infiltration of TIM-1 in cancers. TCGA …
has revealed the distribution, prognosis, and immune infiltration of TIM-1 in cancers. TCGA …
[HTML][HTML] Expression of Tim-3 in gastric cancer tissue and its relationship with prognosis
G Cheng, M Li, J Wu, M Ji, C Fang, H Shi… - … journal of clinical and …, 2015 - ncbi.nlm.nih.gov
As a negative regulatory molecule, T-cell immunoglobulin–and mucin domain-3 (Tim-3)
plays a crucial role in the tumor immunological tolerance. In the present study, we aimed to …
plays a crucial role in the tumor immunological tolerance. In the present study, we aimed to …
Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer
Background T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and
plays a crucial part in tumor-induced immune suppression. However, the mechanism of …
plays a crucial part in tumor-induced immune suppression. However, the mechanism of …