Background: T-cell immunoglobulin domain and mucin domain 4 (TIM-4) is exclusively
expressed in antigen-presenting cells and involved in immune regulation. However, the role …

Background T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is a
crucial immune checkpoint and is considered as an emerging target for cancer treatment …

TIM-3 functions to enforce CD8+ T cell exhaustion, a dysfunctional state associated with the
tolerization of tumor microenvironment. Here we report apoptosis of IFN-γ competent TIM-3+ …

Objective Tumour-associated macrophages (TAMs) and their alternative activation
contribute greatly to the development of hepatocellular carcinoma (HCC). Tim-3 is highly …

Abstract Objectives Interleukin‐6 (IL‐6) is critical for the development of non‐small‐cell lung
cancer (NSCLC). Recently, we identified T‐cell immunoglobulin domain and mucin domain …

Gamma delta (γδ) T cell-based tumor immunotherapy has been one of the most promising
cancer immunotherapeutic strategies. However, the key regulators of the Vγ9Vδ2 T cell …

T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates
innate and adaptive immunity in cancer. To identify the mechanisms of Tim-3 in cancer …

Objective: Ovarian cancer (OV) is the most fatal and frequent type of gynaecological
malignancy worldwide. TIMELESS, as a circadian clock gene, has been found to be highly …

T‐cell immunoglobulin mucin 3 (TIM 3) contributes to immune suppression during
progression of many cancers, but the precise role of TIM 3 in head and neck squamous cell …

One of the most common tumors in the world is hepatocellular carcinoma (HCC), and its
mortality rates are still on the rise, so addressing it is considered an important challenge for …