AML is the most common blood cancer in adults with a high relapse and an overall poor
survival rate. NK cells have been demonstrated to have the capacity to eradicate AML blast …

Given the heightened interest in manipulation of co-signaling cascades for cancer
immunotherapy, we sought to determine how/whether tumors decorated with therapeutic …

T cell Ig-like mucin-like–1 (TIM-1) is an important asthma susceptibility gene, but the
immunological mechanisms by which TIM-1 functions remain uncertain. TIM-1 is also a …

Purpose Co-signaling molecules play an important role in T cells. This study was designed
to investigate PD-1 and Tim-3 expression on T cells and the relationships between PD-1 …

Background: In this study, the expression pattern of NKp30 and T cell immunoglobulin and
mucin domain-containing molecule-3 (Tim-3), as candidates for activating and inhibitory …

STAT3 is an important transcriptional factor for cell growth, differentiation, and apoptosis.
Although evidence suggests a positive role for STAT3 in cancer, the inhibitory effects of …

Background T cell immunoglobulin mucin‐3 (Tim‐3) was initially recognized as a pivotal
immune checkpoint inhibitor that maintains immune homeostasis and tolerance. Recently …

Tumor immunosurveillance relies on cognate immune effectors [lymphocytes and interferon‐
γ (IFN‐γ)] and innate immunity [natural killer (NK) cells, natural killer group 2, member D …

Upregulation of T cell immunoglobulin-3 (TIM-3) has been associated with negative
regulation of the immune response in chronic infection and cancer, including lymphoma …

T cell immunoglobulin-3 (Tim-3) was identified nearly 10 years ago as a negative regulator
of IFN-γ-secreting CD4+ T helper 1 and CD8+ T cytotoxic 1 cells. Tim-3 is now classed with …