Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia
Q Zhou, ME Munger, RG Veenstra… - Blood, The Journal …, 2011 - ashpublications.org
Tumor-associated immune suppression can lead to defective T cell-mediated antitumor
immunity. Here, we identified a unique phenotype of exhausted T cells in mice with …
immunity. Here, we identified a unique phenotype of exhausted T cells in mice with …
CRISPR-Cas9–Mediated TIM3 knockout in human natural killer cells enhances growth inhibitory effects on human glioma cells
T Morimoto, T Nakazawa, R Matsuda… - International journal of …, 2021 - mdpi.com
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in
adults. Natural Killer (NK) cells are potent cytotoxic effector cells against tumor cells inducing …
adults. Natural Killer (NK) cells are potent cytotoxic effector cells against tumor cells inducing …
Blocking Tim-3 or/and PD-1 reverses dysfunction of tumor-infiltrating lymphocytes in HBV-related hepatocellular carcinoma
F Liu, G Zeng, S Zhou, X He, N Sun, X Zhu, A Hu - Bulletin du cancer, 2018 - Elsevier
Background The immunosuppression of tumor-infiltrating lymphocytes (TILs) is associated
with rapid progression of hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). T …
with rapid progression of hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). T …
[HTML][HTML] Expression of immune checkpoints in T cells of esophageal cancer patients
J Xie, JI Wang, S Cheng, L Zheng, F Ji, L Yang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Inhibition of immune checkpoint proteins (checkpoints) has become a promising anti-
esophageal cancer strategy. We here tested expressions of immune checkpoints in human …
esophageal cancer strategy. We here tested expressions of immune checkpoints in human …
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients
J Fourcade, Z Sun, M Benallaoua… - Journal of Experimental …, 2010 - rupress.org
The paradoxical coexistence of spontaneous tumor antigen–specific immune responses
with progressive disease in cancer patients furthers the need to dissect the molecular …
with progressive disease in cancer patients furthers the need to dissect the molecular …
Immunoregulation of dendritic cells by the receptor T cell Ig and mucin protein-3 via Bruton's tyrosine kinase and c-Src
The receptor T cell Ig and mucin protein-3 (TIM-3) has emerged as an important regulator of
innate immune responses. However, whether TIM-3–induced signaling promotes or inhibits …
innate immune responses. However, whether TIM-3–induced signaling promotes or inhibits …
Natural Killer Cells Induce CD8+ T Cell Dysfunction via Galectin-9/TIM-3 in Chronic Hepatitis B Virus Infection
S Liu, C Xu, F Yang, L Zong, Y Qin, Y Gao… - Frontiers in …, 2022 - frontiersin.org
The antiviral response of natural killer (NK) cells and CD8+ T cells is weak in patients with
chronic hepatitis B (CHB) infection. However, the specific characteristics of these cells and …
chronic hepatitis B (CHB) infection. However, the specific characteristics of these cells and …