Background Despite the efforts to describe the molecular landscape of esophageal
adenocarcinoma (EAC) and its precursor lesion Barrett's esophagus (BE), discrepant …

Background & Aims Esophageal adenocarcinomas (EACs) are heterogeneous and often
preceded by Barrett's esophagus (BE). Many genomic changes have been associated with …

Barrett's esophagus (BE) is a metaplastic process whereby the normal stratified, squamous
esophageal epithelium is replaced by specialized intestinal epithelium. Barrett's is the only …

Although the molecular basis of esophageal adeno-carcinoma (EAC) and its precursor,
Barrett's esophagus (BE), have been studied, further insights are needed into early …

Esophageal adenocarcinoma (EAC) arises after normal squamous mucosa undergoes
metaplasia to specialized columnar epithelium (intestinal metaplasia or Barrett's …

We have recently gained unprecedented insight into genetic factors that determine risk for
Barrett's esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next …

Objective To identify and characterise DNA methylation subtypes in oesophageal
adenocarcinoma (EAC) and its precursor Barrett's oesophagus (BE). Design We performed …

Barrett's esophagus, a pre-malignant condition that can lead to esophageal
adenocarcinoma, is characterized by histological changes in the normal squamous …

The aberrant DNA methylation of tumor suppressor genes is well documented in
esophageal cancer, including adenocarcinoma (EAC) and squamous cell carcinoma …

Background Recent studies have identified age-related changes in DNA methylation
patterns in normal and cancer tissues in a process that is called epigenetic drift. However …