Understanding cancer biology and the development of novel agents for cancer treatment
has always been the goal of cancer researchers. However, the research and development of …

Itraconazole (ITZ) is an anti-fungal drug that has been used in clinical practice for nearly 35
years. Recently, numerous experiments have shown that ITZ possesses anti-cancer …

The repurposing of drugs is becoming increasingly attractive as it avoids the lengthy process
and cost implications associated with bringing a novel drug to market. Itraconazole is a …

Itraconazole, a common anti-fungal agent, has demonstrated potential anticancer activity,
including reversing chemoresistance mediated by P-glycoprotein, modulating the signal …

Purpose Itraconazole is an antifungal drug that has been clinically used for over 30 years. In
recent years, scholars have discovered that it possesses an anticancer effect. Moreover, its …

Itraconazole, a common triazole anti-fungal drug in widespread clinical use, has evidence of
clinical activity that is of interest in oncology. There is evidence that at the clinically relevant …

Itraconazole is a common antifungal which may have promise for treating various human
cancers. We report that itraconazole was cytotoxic to MCF-7 and SKBR-3 breast cancer cell …

Introduction: The Hedgehog (Hh) signaling pathway is known to be dysregulated in several
forms of cancer. Hence, specifically targeting this signaling cascade is a valid and promising …

The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore
presents an attractive target for new anticancer agents. Here, we show that mebendazole, a …

Background Itraconazole has been proved therapeutically effective against a variety of
human cancers. This study assessed the effect of itraconazole on the Hedgehog (Hh) …