Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans

S Sachs, S Zarini, DE Kahn… - American Journal …, 2019 - journals.physiology.org
Intermuscular adipose tissue (IMAT) is negatively related to insulin sensitivity, but a causal
role of IMAT in the development of insulin resistance is unknown. IMAT was sampled in …

Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction

NK Biltz, KH Collins, KC Shen… - The Journal of …, 2020 - Wiley Online Library
Key points Muscle infiltration with adipose tissue (IMAT) is common and associated with loss
of skeletal muscle strength and physical function across a diverse set of pathologies …

Intermuscular adipose tissue in metabolic disease

BH Goodpaster, BC Bergman, AM Brennan… - Nature Reviews …, 2023 - nature.com
Intermuscular adipose tissue (IMAT) is a distinct adipose depot described in early reports as
a 'fatty replacement'or 'muscle fat infiltration'that was linked to ageing and neuromuscular …

Intermuscular adipose tissue (IMAT): association with other adipose tissue compartments and insulin sensitivity

M Boettcher, J Machann, N Stefan… - Journal of Magnetic …, 2009 - Wiley Online Library
Purpose To quantify intermuscular adipose tissue (IMAT) of the lower leg as well as to
investigate associations with other adipose tissue (AT) compartments. The relationship …

Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction

JC Murphy, JL McDaniel, K Mora… - Journal of Applied …, 2012 - journals.physiology.org
Intermuscular adipose tissue (IMAT) and visceral adipose tissue (VAT) are associated with
insulin resistance. We sought to determine whether exercise-induced weight loss (EX) …

The origin of intermuscular adipose tissue and its pathophysiological implications

R Vettor, G Milan, C Franzin, M Sanna… - American Journal …, 2009 - journals.physiology.org
The intermuscular adipose tissue (IMAT) is a depot of adipocytes located between muscle
bundles. Several investigations have recently been carried out to define the phenotype, the …

Intermuscular adipose tissue rivals visceral adipose tissue in independent associations with cardiovascular risk

JE Yim, S Heshka, J Albu, S Heymsfield… - International journal of …, 2007 - nature.com
Background: The metabolic implications of intermuscular adipose tissue (IMAT) are poorly
understood compared to those of visceral adipose tissue (VAT) even though the absolute …

Subcutaneous adipose tissue and systemic inflammation are associated with peripheral but not hepatic insulin resistance in humans

BW Van der Kolk, M Kalafati, M Adriaens… - Diabetes, 2019 - Am Diabetes Assoc
Obesity-related insulin resistance (IR) may develop in multiple organs, representing various
etiologies for cardiometabolic diseases. We identified abdominal subcutaneous adipose …

Intramuscular adipose tissue and central activation in older adults

Y Yoshida, RL Marcus, PC Lastayo - Muscle & nerve, 2012 - Wiley Online Library
Introduction: Intramuscular adipose tissue (IMAT) is a potential contributor to declining force
production and may be related to impaired central activation; therefore, the purpose of this …

Excessive adipose tissue infiltration in skeletal muscle in individuals with obesity, diabetes mellitus, and peripheral neuropathy: association with performance and …

TN Hilton, LJ Tuttle, KL Bohnert, MJ Mueller… - Physical …, 2008 - academic.oup.com
Background and Purpose The primary purpose of this study was to report differences in calf
intermuscular adipose tissue (IMAT), muscle strength (peak torque), power, and physical …