Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies

TE Hutson, RA Figlin, JG Kuhn, RJ Motzer - The oncologist, 2008 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader should be able to:
Evaluate the recommended clinical doses and the associated safety data for targeted …

Onconephrology: what should the internist know about targeted therapy in solid tumors?

E El Rassy, F El Karak, J Rizkallah… - Iranian Journal of …, 2016 - search.ebscohost.com
Advances in medical oncology has led cancer patients to live longer. Moreover, the field of
molecular oncology is rapidly evolving, new therapies emerge, and drugs are approved …

Chronic kidney disease as a complication of cancer

U Selamet, A Abudayyeh - Journal of Onco-Nephrology, 2017 - journals.sagepub.com
An exciting era in the diagnosis and treatment of cancer has emerged in the last 2 decades.
What was once an often deadly disease has, for many patients, become a chronic disease …

Management of treatment-related toxicity with targeted therapies for renal cell carcinoma: evidence-based practice and best practices

L Appleby, S Morrissey, J Bellmunt… - Hematology …, 2011 - hemonc.theclinics.com
The advent of targeted agents for the treatment of advanced renal cell carcinoma has led to
dramatic improvements in therapy. However, the chronic use of these medications has also …

Long–term renal outcomes after cisplatin treatment

S Latcha, EA Jaimes, S Patil… - Clinical Journal of the …, 2016 - journals.lww.com
Results Mean follow-up was 6 years (25th and 75th percentiles, 4 and 9 years). AKI
occurred in 31.5% of patients, with a median initial decline in eGFR of 10 ml/min per 1.73 m …

Metastatic renal cell carcinoma: how to make the best sequencing decision after withdrawal for intolerance to a tyrosine kinase inhibitor

R Sabbatini, C Ortega, G Procopio, C Masini… - Future …, 2013 - Taylor & Francis
With seven agents approved for metastatic renal cell carcinoma (RCC) within the past few
years, there has undoubtedly been progress in treating this disease. The treatment safety of …

Update on the nephrotoxicity of novel anticancer agents

EZ Nussbaum, MA Perazella - Clinical Nephrology, 2018 - search.proquest.com
Anticancer drug-induced kidney disease is a problem commonly encountered by
nephrologists. The number of medications employed by oncologists causing acute and …

Importance of monitoring renal function in patients with cancer

M Aapro, V Launay-Vacher - Cancer treatment reviews, 2012 - Elsevier
Monitoring renal function in patients with solid tumors and hematologic malignancies is vital
to the safe administration of therapeutic agents. Renal impairment is frequent in elderly …

Toxicity associated with the long-term use of targeted therapies in patients with advanced renal cell carcinoma

DR Shepard, JA Garcia - Expert review of anticancer therapy, 2009 - Taylor & Francis
VEGF and mTOR inhibitors have encouraging clinical activity for patients with advanced
renal cell carcinoma (RCC), but may lead to significant short-and long-term toxicities …

Cisplatin dose adjustment in patients with renal impairment, which recommendations should we follow?

Y Bennis, A Savry, M Rocca, L Gauthier-Villano… - International journal of …, 2014 - Springer
Background Nephrotoxicity is the dose-limiting side effect of cisplatin justifying the
assessment of renal function for dose adjustment. Objective To determine whether …