Formulating 10-hydroxycamptothecin into nanoemulsion with functional excipient tributyrin: An innovative strategy for targeted hepatic cancer chemotherapy
This study aimed to develop an innovative dosage form for 10-hydroxycamptothecin (HCPT),
a chemotherapeutic agent with limited aqueous solubility and stability, to enhance its …
a chemotherapeutic agent with limited aqueous solubility and stability, to enhance its …
Preparation, characterization and biodistribution of the lactone form of 10-hydroxycamptothecin (HCPT)-loaded bovine serum albumin (BSA) nanoparticles
L Yang, F Cui, D Cun, A Tao, K Shi, W Lin - International journal of …, 2007 - Elsevier
10-Hydroxycamptothecin (HCPT) is insoluble in both water and physiological acceptable
organic solvents and tends to change into its carboxylate form, which shows minimal …
organic solvents and tends to change into its carboxylate form, which shows minimal …
Preparation, characterization, biodistribution and antitumor efficacy of hydroxycamptothecin nanosuspensions
M Han, X Liu, Y Guo, Y Wang, X Wang - International journal of …, 2013 - Elsevier
Hydroxycamptothecin (HCPT) has shown activity against a broad spectrum of cancers, but
its therapeutic efficacy is impaired by its poor solubility and delivery challenges. In this study …
its therapeutic efficacy is impaired by its poor solubility and delivery challenges. In this study …
In vivo antitumor and antimetastatic activities of camptothecin encapsulated with N-trimethyl chitosan in a preclinical mouse model of liver cancer
L Zhou, X Li, X Chen, Z Li, X Liu, S Zhou, Q Zhong, T Yi… - Cancer letters, 2010 - Elsevier
Application of camptothecin (CPT) is hampered due to its extreme water insolubility and
unpredictable side effects. Therefore, it is essential to establish an efficient and safe protocol …
unpredictable side effects. Therefore, it is essential to establish an efficient and safe protocol …
In-vivo pharmacokinetics, tissue distribution and anti-tumour effect of hydroxycamptothecin delivered in oil-in-water submicron emulsions
YX Zhao, DX Liu, WQ Liang… - Journal of Pharmacy and …, 2012 - academic.oup.com
Objectives The aim of this study was to investigate the pharmacokinetics, tissue distribution
and anti-tumour effect of hydroxycamptothecin submicron emulsions (HCPT-SEs). Methods …
and anti-tumour effect of hydroxycamptothecin submicron emulsions (HCPT-SEs). Methods …
Galactosylated Nanocrystallites of Insoluble Anticancer Drug for Liver-Targeting Therapy: An In Vitro Evaluation
Aim: Low solubility in water has become an intrinsic property of many anticancer drugs,
which poses a hurdle in the translation from the bench to the clinic. In this study, we …
which poses a hurdle in the translation from the bench to the clinic. In this study, we …
A stabilizer-free and organic solvent-free method to prepare 10-hydroxycamptothecin nanocrystals: in vitro and in vivo evaluation
X Yang, Y Liu, Y Zhao, M Han, Y Guo… - International Journal …, 2016 - Taylor & Francis
10-Hydroxycamptothecin (10-HCPT) is a promising anticancer drug with a wide spectrum of
antitumor activities. Due to its poor solubility, the carboxylate form that shows high water …
antitumor activities. Due to its poor solubility, the carboxylate form that shows high water …
10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy
L Yang, J Hong, J Di, Y Guo, M Han… - International Journal of …, 2017 - Taylor & Francis
In this study, polyethylene glycol (PEG) ylated 10-hydroxycamptothecin (mPEG1000-HCPT)
was synthesized and used as a stabilizer to prepare 10-hydroxycamptothecin (HCPT) …
was synthesized and used as a stabilizer to prepare 10-hydroxycamptothecin (HCPT) …
[HTML][HTML] Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect
A Wang, S Li - BMC biotechnology, 2008 - Springer
Background Hydroxycamptothecin (HCPT) has been shown to have activity against a broad
spectrum of cancers. In order to enhance its tissue-specific delivery and anticancer activity …
spectrum of cancers. In order to enhance its tissue-specific delivery and anticancer activity …
A novel camptothecin derivative incorporated in nano-carrier induced distinguished improvement in solubility, stability and anti-tumor activity both in vitro and in vivo
Purpose An oil/water nanoemulsion was developed in the present study to enhance the
solubility, stability and anti-tumor activity of a novel 10-methoxy-9-nitrocamptothecin …
solubility, stability and anti-tumor activity of a novel 10-methoxy-9-nitrocamptothecin …