Abstract The 2010 Lasker Award for basic medical research was shared by Douglas
Coleman and Jeffery Friedman for their discovery of leptin, a breakthrough that revealed …

The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

This issue of the journal Metabolism celebrates the 20 years since the discovery of the
prototypical adipose tissue secreted hormone leptin [1],[2],[3],[4],[5],[6],[7],[8],[9]. Leptin has …

The identification of the ob gene through positional cloning (1) and the demonstration that its
protein product leptin reverses the obesity–diabetes syndrome in ob/ob mice (2–4) have …

Leptin is an adipose tissue hormone that functions as an afferent signal in a negative
feedback loop that maintains homeostatic control of adipose tissue mass. This endocrine …

This year, the Albert Lasker Basic Medical Research Award will be shared by Douglas
Coleman and Jeffrey Friedman for their discovery of leptin, a hormone that regulates …

Historically, adipose tissue was considered to be a passive storage vessel discharging
nutrients in times of famine and accumulating fat in times of surfeit. This view changed with …

Leptin has received considerable attention as a newly recognized metabolic hormone and
for its potential for therapeutic use in the treatment of human obesity. Furthermore, defects in …

The discovery of the obese gene and the demonstration that its encoded protein leptin can
reverse obesity due to genetic deficiency of the hormone were landmark discoveries in …

Despite significant reductions in the consumption of dietary fat, the prevalence of obesity is
steadily rising in western civilization. Of particular concern is the recent epidemic of …