Parkinson's disease: a rethink of rodent models
HL Melrose, SJ Lincoln, GM Tyndall… - Experimental Brain …, 2006 - Springer
Parkinson's disease (PD) is a multifactorial disease with a complex etiology that results from
genetic risk factors, environmental exposures and most likely a combination of both. Rodent …
genetic risk factors, environmental exposures and most likely a combination of both. Rodent …
Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions
A Dovonou, C Bolduc, V Soto Linan, C Gora… - Translational …, 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …
Animal models of Parkinson's disease: a guide to selecting the optimal model for your research
Parkinson's disease (PD) is a complex, multisystem disorder characterised by α-synuclein
(SNCA) pathology, degeneration of nigrostriatal dopaminergic neurons, multifactorial …
(SNCA) pathology, degeneration of nigrostriatal dopaminergic neurons, multifactorial …
Value of genetic models in understanding the cause and mechanisms of Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized
pathologically by the degeneration of nigrostriatal pathway dopaminergic neurons and other …
pathologically by the degeneration of nigrostriatal pathway dopaminergic neurons and other …
Animal models for preclinical Parkinson's research: an update and critical appraisal
MA Cenci, A Björklund - Progress in brain research, 2020 - Elsevier
Animal models of Parkinson's disease (PD) are essential to investigate pathogenic
pathways at the whole-organism level. Moreover, they are necessary for a preclinical …
pathways at the whole-organism level. Moreover, they are necessary for a preclinical …
[图书][B] Animal models of Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the
degeneration of dopaminergic neurons in the substantia nigra pars compacta, the …
degeneration of dopaminergic neurons in the substantia nigra pars compacta, the …
Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems
RM Miller, HJ Federoff - The Neuroscientist, 2005 - journals.sagepub.com
Parkinson disease (PD) targets dopaminergic neurons in the substantia nigra, resulting in
motor disturbances such as resting tremor, bradykinesia, and rigidity. Pathogenic processes …
motor disturbances such as resting tremor, bradykinesia, and rigidity. Pathogenic processes …
Disease model: Parkinson's disease
S Shimohama, H Sawada, Y Kitamura… - Trends in molecular …, 2003 - cell.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is primarily
characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway …
characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway …
Animal models of Parkinson's disease: vertebrate genetics
Parkinson's disease (PD) is a complex genetic disorder that is associated with
environmental risk factors and aging. Vertebrate genetic models, especially mice, have …
environmental risk factors and aging. Vertebrate genetic models, especially mice, have …
Animal models of Parkinson's disease: An updated overview
P Gubellini, P Kachidian - Revue neurologique, 2015 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology,
besides a minority of genetic cases, is still largely unknown. Animal models have contributed …
besides a minority of genetic cases, is still largely unknown. Animal models have contributed …