The formation of an obstructive thrombus within an artery remains a major cause of mortality
and morbidity worldwide. Despite effective inhibition of platelet function by modern …

Most acute cardiovascular events are attributable to arterial thrombosis. Plaque rupture or
erosion stimulates platelet activation, aggregation, and thrombosis, whilst simultaneously …

Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

Fibrin is a major component of thrombi formed on the surface of atherosclerotic plaques.
Fibrin accumulation as a consequence of local blood coagulation activation takes place …

Endogenous fibrinolysis is a powerful natural defense mechanism against lasting arterial
thrombotic occlusion. Recent prospective studies have shown that impaired endogenous …

Fibrin plays an essential role in hemostasis as both the primary product of the coagulation
cascade and the ultimate substrate for fibrinolysis. Fibrinolysis efficiency is greatly …

Spontaneous thrombolysis is an endogenous protective mechanism against lasting arterial
thrombotic occlusion, which is implicated in the pathogenesis of myocardial infarction and …

Highlights•Despite the availability of revascularization strategies the care of heart disease
and stroke patients remains challenging.•There is an unmet clinical need to explore novel …

The development of an obstructive luminal thrombus is pathological and considered a
failure of endogenous fibrinolysis. The consequences may be fatal, or result in lasting …

Fibrinogen is a complex glycoprotein that is known to play a significant role in the process of
thrombus formation and evolution, and has been linked to the pathophysiology of …