Summary The endothelins (ET-1, 2, and 3) constitute a family of 21 amino-acid peptides with
potent biological activities. They are synthesized in several tissues, including the vascular …

The endothelins are a family of endothelium-derived peptides that possess characteristically
sustained vasoconstrictor properties. Endothelin-1 appears to be the predominant member …

The discovery of endothelin two decades ago has now evolved into an intricate vascular
endothelin (ET) system. Several ET isoforms, receptors, signaling pathways, agonists …

Endothelin-1 (ET-1) is a potent vasoconstrictive peptide produced by endothelial cells of
blood vessels. This peptide has quite a unique structure and pharmacological properties. ET …

Endothelin-1 is a recently discovered peptide mainly released from endothelial cells.
Hypoxia and ischemia as well as numerous factors such as angiotensin 11, thrombin and …

The endothelins (ET) are potent 21-amino-acid vasoconstrictor peptides produced in many
different tissues, particularly in the endothelium of blood vessels. ET-1 is the main …

Endothelins are powerful vasoconstrictor peptides that also play numerous other functions in
many different organs. Endothelin-1 (ET-1) is the most abundant and important of this family …

Endothelins are potent 21 amino acid vasoconstrictor isopeptides produced in different
vascular tissues, including vascular endothelium. Endothelin-1 is the main endothelin …

Abstract The endothelins, 21-amino-acid peptides produced by the endothelium of blood
vessels and many other tissues such as the kidney, brain, endocrine organs, etc., are potent …

The role of endothelins (ET) in blood pressure elevation remains controversial. Data
supporting involvement of the ET system in different forms of genetic and experimental …