Genomic profiling of prostate cancers from men with African and European ancestry

Y Koga, H Song, ZR Chalmers, J Newberg, E Kim… - Clinical Cancer …, 2020 - AACR
Abstract Purpose: African American (AFR) men have the highest mortality rate from prostate
cancer (PCa) compared with men of other racial/ancestral groups. Differences in the …

[HTML][HTML] Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry

J Yuan, KH Kensler, Z Hu, Y Zhang, T Zhang… - PLoS …, 2020 - journals.plos.org
Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence
and worse survival than men of predominantly European Ancestry (EA). While …

Differences in prostate cancer genomes by self-reported race: contributions of genetic ancestry, modifiable cancer risk factors, and clinical factors

KH Stopsack, S Nandakumar, K Arora, B Nguyen… - Clinical Cancer …, 2022 - AACR
Purpose: Black men die from prostate cancer twice as often as White men, a disparity likely
due to inherited genetics, modifiable cancer risk factors, and healthcare access. It is …

Whole-genome sequencing reveals elevated tumor mutational burden and initiating driver mutations in African men with treatment-naïve, high-risk prostate cancer

W Jaratlerdsiri, EKF Chan, T Gong, DC Petersen… - Cancer research, 2018 - AACR
African-American men are more likely than any other racial group to die from prostate
cancer. The contribution of acquired genomic variation to this racial disparity is largely …

Mutational landscape of aggressive prostate tumors in African American men

KJ Lindquist, PL Paris, TJ Hoffmann, NJ Cardin… - Cancer research, 2016 - AACR
Prostate cancer is the most frequently diagnosed and second most fatal nonskin cancer
among men in the United States. African American men are two times more likely to develop …

[HTML][HTML] Prostate cancer genomics: recent advances and the prevailing underrepresentation from racial and ethnic minorities

SH Tan, G Petrovics, S Srivastava - International journal of molecular …, 2018 - mdpi.com
Prostate cancer (CaP) is the most commonly diagnosed non-cutaneous cancer and the
second leading cause of male cancer deaths in the United States. Among African American …

[HTML][HTML] Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers

T Gong, W Jaratlerdsiri, J Jiang, C Willet, T Chew… - Genome medicine, 2022 - Springer
Background African ancestry is a significant risk factor for advanced prostate cancer (PCa).
Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the …

Whole-genome and transcriptome sequencing of prostate cancer identify new genetic alterations driving disease progression

S Ren, GH Wei, D Liu, L Wang, Y Hou, S Zhu, L Peng… - European urology, 2018 - Elsevier
Background Global disparities in prostate cancer (PCa) incidence highlight the urgent need
to identify genomic abnormalities in prostate tumors in different ethnic populations including …

Mutational profile of aggressive, localised prostate cancer from African Caribbean men versus European ancestry men

L Tonon, G Fromont, S Boyault, E Thomas, A Ferrari… - European Urology, 2019 - Elsevier
Causes of high mortality of prostate cancer in men of African ancestry living in the French
West Indies are still debated, between suspicions of environmental factors and genetic …

Minireview: the molecular and genomic basis for prostate cancer health disparities

IJ Powell, A Bollig-Fischer - Molecular endocrinology, 2013 - academic.oup.com
Despite more aggressive screening across all demographics and gradual declines in
mortality related to prostate cancer (PCa) in the United States, race disparities persist. For …