Genomic profiling of prostate cancers from men with African and European ancestry
Abstract Purpose: African American (AFR) men have the highest mortality rate from prostate
cancer (PCa) compared with men of other racial/ancestral groups. Differences in the …
cancer (PCa) compared with men of other racial/ancestral groups. Differences in the …
[HTML][HTML] Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry
Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence
and worse survival than men of predominantly European Ancestry (EA). While …
and worse survival than men of predominantly European Ancestry (EA). While …
Differences in prostate cancer genomes by self-reported race: contributions of genetic ancestry, modifiable cancer risk factors, and clinical factors
Purpose: Black men die from prostate cancer twice as often as White men, a disparity likely
due to inherited genetics, modifiable cancer risk factors, and healthcare access. It is …
due to inherited genetics, modifiable cancer risk factors, and healthcare access. It is …
Whole-genome sequencing reveals elevated tumor mutational burden and initiating driver mutations in African men with treatment-naïve, high-risk prostate cancer
African-American men are more likely than any other racial group to die from prostate
cancer. The contribution of acquired genomic variation to this racial disparity is largely …
cancer. The contribution of acquired genomic variation to this racial disparity is largely …
Mutational landscape of aggressive prostate tumors in African American men
KJ Lindquist, PL Paris, TJ Hoffmann, NJ Cardin… - Cancer research, 2016 - AACR
Prostate cancer is the most frequently diagnosed and second most fatal nonskin cancer
among men in the United States. African American men are two times more likely to develop …
among men in the United States. African American men are two times more likely to develop …
[HTML][HTML] Prostate cancer genomics: recent advances and the prevailing underrepresentation from racial and ethnic minorities
SH Tan, G Petrovics, S Srivastava - International journal of molecular …, 2018 - mdpi.com
Prostate cancer (CaP) is the most commonly diagnosed non-cutaneous cancer and the
second leading cause of male cancer deaths in the United States. Among African American …
second leading cause of male cancer deaths in the United States. Among African American …
[HTML][HTML] Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers
Background African ancestry is a significant risk factor for advanced prostate cancer (PCa).
Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the …
Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the …
Whole-genome and transcriptome sequencing of prostate cancer identify new genetic alterations driving disease progression
Background Global disparities in prostate cancer (PCa) incidence highlight the urgent need
to identify genomic abnormalities in prostate tumors in different ethnic populations including …
to identify genomic abnormalities in prostate tumors in different ethnic populations including …
Mutational profile of aggressive, localised prostate cancer from African Caribbean men versus European ancestry men
L Tonon, G Fromont, S Boyault, E Thomas, A Ferrari… - European Urology, 2019 - Elsevier
Causes of high mortality of prostate cancer in men of African ancestry living in the French
West Indies are still debated, between suspicions of environmental factors and genetic …
West Indies are still debated, between suspicions of environmental factors and genetic …
Minireview: the molecular and genomic basis for prostate cancer health disparities
IJ Powell, A Bollig-Fischer - Molecular endocrinology, 2013 - academic.oup.com
Despite more aggressive screening across all demographics and gradual declines in
mortality related to prostate cancer (PCa) in the United States, race disparities persist. For …
mortality related to prostate cancer (PCa) in the United States, race disparities persist. For …