Adipose-derived stem cells promote diabetic wound healing via the recruitment and differentiation of endothelial progenitor cells into endothelial cells mediated by the …

L Chen, Q Zheng, Y Liu, L Li, X Chen, L Wang… - Archives of Biochemistry …, 2020 - Elsevier
Adipose-derived stem cell (ADSC) therapy is a promising treatment strategy for wound
healing; however, the mechanism underlying this effect remains unclear. In the present …

[HTML][HTML] Adipose-derived stem cells: effectiveness and advances in delivery in diabetic wound healing

M Gadelkarim, AI Abushouk, E Ghanem… - Biomedicine & …, 2018 - Elsevier
With the increasing global prevalence of diabetes mellitus, a significant rise in the number of
patients suffering from non-healing wounds is expected. However, available treatments …

Adipose-derived stem cells accelerate diabetic wound healing through the induction of autocrine and paracrine effects

YR Kuo, CT Wang, JT Cheng, GS Kao… - Cell …, 2016 - journals.sagepub.com
Cell-based therapy is an attractive approach for the treatment of chronic nonhealing
wounds. This study investigated whether adipose-derived stem cells (ASCs) can accelerate …

Extracellular vesicles from adipose-derived stem cells promote diabetic wound healing via the PI3K-AKT-mTOR-HIF-1α signaling pathway

W Liu, Y Yuan, D Liu - Tissue Engineering and Regenerative Medicine, 2021 - Springer
Background: Impaired potential of hypoxia-mediated angiogenesis lead poor healing of
diabetic wounds. Previous studies have shown that extracellular vesicles from adipose …

Adipose-derived stem cells combined with platelet-rich plasma enhance wound healing in a rat model of full-thickness skin defects

X Ni, X Shan, L Xu, W Yu, M Zhang, C Lei, N Xu… - Stem cell research & …, 2021 - Springer
Background Wound healing is impaired in patients with diabetes due to the multifactorial
etiology of the disease, which limits the therapeutic efficacy of various approaches. This …

Locally administered adipose-derived stem cells accelerate wound healing through differentiation and vasculogenesis

C Nie, D Yang, J Xu, Z Si, X Jin… - Cell …, 2011 - journals.sagepub.com
Despite advances in wound closure techniques and devices, there is still a critical need for
new methods of enhancing the healing process to achieve optimal outcomes. Recently …

Human fibroblast growth factor-treated adipose-derived stem cells facilitate wound healing and revascularization in rats with streptozotocin-induced diabetes mellitus

SY Chang, JH Lee, SC Oh, MY Lee, NK Lim - Cells, 2023 - mdpi.com
Diabetes mellitus contributes to 15–25% of all chronic foot ulcers. Peripheral vascular
disease is a cause of ischemic ulcers and exacerbates diabetic foot disease. Cell-based …

Diabetic human adipose-derived stem cells accelerate pressure ulcer healing by inducing angiogenesis and neurogenesis

S Xiao, Z Liu, Y Yao, ZR Wei, D Wang… - Stem Cells and …, 2019 - liebertpub.com
Adipose-derived stem cells (ASCs) possess a well-characterized capacity to enhance
cutaneous wound healing. However, many controversies exist regarding ASCs from diabetic …

Adipose-derived Mesenchymal Stem Cells are Ideal for the Cell-based Treatment of Refractory Wounds: Strong Potential for Angiogenesis

Y Cao, J Yan, Z Dong, J Wang, X Jiang, T Cui… - Stem Cell Reviews and …, 2024 - Springer
Abstract Although Mesenchymal Stem Cells (MSCs)-based therapy has been proposed as a
promising strategy for the treatment of chronic lower-extremity ulcers, their optimal sources …

Diabetes impairs adipose tissue–derived stem cell function and efficiency in promoting wound healing

F Cianfarani, G Toietta, G Di Rocco… - Wound repair and …, 2013 - Wiley Online Library
Adipose tissue–derived stem cells (ASC s) are gaining increasing consideration in tissue
repair therapeutic application. Recent evidence indicates that ASC s enhance skin repair in …