Posttraumatic stress disorder-like induction elevates β-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses
Recent studies have found that those who suffer from posttraumatic stress disorder (PTSD)
are more likely to experience dementia as they age, most often Alzheimer's disease (AD) …
are more likely to experience dementia as they age, most often Alzheimer's disease (AD) …
Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a …
JC Carroll, M Iba, DA Bangasser… - Journal of …, 2011 - Soc Neuroscience
Because overactivation of the hypothalamic–pituitary–adrenal (HPA) axis occurs in
Alzheimer's disease (AD), dysregulation of stress neuromediators may play a mechanistic …
Alzheimer's disease (AD), dysregulation of stress neuromediators may play a mechanistic …
3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress
SM Rothman, N Herdener, S Camandola, SJ Texel… - Neurobiology of …, 2012 - Elsevier
Chronic stress may be a risk factor for developing Alzheimer's disease (AD), but most
studies of the effects of stress in models of AD utilize acute adverse stressors of …
studies of the effects of stress in models of AD utilize acute adverse stressors of …
Central CRF system perturbation in an Alzheimer's disease knockin mouse model
Q Guo, H Zheng, NJ Justice - Neurobiology of aging, 2012 - Elsevier
Alzheimer's disease (AD) is often accompanied by changes in mood as well as increases in
circulating cortisol levels, suggesting that regulation of the stress responsive hypothalamic …
circulating cortisol levels, suggesting that regulation of the stress responsive hypothalamic …
Targeting psychologic stress signaling pathways in Alzheimer's disease
Alzheimer's Disease (AD) is the most prevalent progressive neurodegenerative disease; to
date, no AD therapy has proven effective in delaying or preventing the disease course. In the …
date, no AD therapy has proven effective in delaying or preventing the disease course. In the …
Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model
L Hoeijmakers, SR Ruigrok, A Amelianchik… - Brain, behavior, and …, 2017 - Elsevier
Exposure to stress during the sensitive period of early-life increases the risk to develop
cognitive impairments and psychopathology later in life. In addition, early-life stress (ES) …
cognitive impairments and psychopathology later in life. In addition, early-life stress (ES) …
Stress reactivity after traumatic brain injury: implications for comorbid post-traumatic stress disorder
AN Hoffman, AN Taylor - Behavioural pharmacology, 2019 - journals.lww.com
Most people have or will experience traumatic stress at some time over the lifespan, but only
a subset of traumatized individuals develop post-traumatic stress disorder (PTSD). Clinical …
a subset of traumatized individuals develop post-traumatic stress disorder (PTSD). Clinical …
Susceptibility to PTSD-like behavior is mediated by corticotropin-releasing factor receptor type 2 levels in the bed nucleus of the stria terminalis
M Lebow, A Neufeld-Cohen, Y Kuperman… - Journal of …, 2012 - Soc Neuroscience
Posttraumatic stress disorder (PTSD) is a debilitating disease, which affects 8–10% of the
population exposed to traumatic events. The factors that make certain individuals …
population exposed to traumatic events. The factors that make certain individuals …
Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease
YB Joshi, J Chu, D Praticò - Journal of Alzheimer's Disease, 2012 - content.iospress.com
Several studies have linked stress with Alzheimer's disease (AD) vulnerability; however, the
mechanism remains to be fully elucidated. In the current paper, we investigated the role of …
mechanism remains to be fully elucidated. In the current paper, we investigated the role of …
3xTg-AD mice exhibit an activated central stress axis during early-stage pathology
EK Hebda-Bauer, TA Simmons, A Sugg… - Journal of …, 2013 - content.iospress.com
Activation of the hypothalamic-pituitary-adrenal (HPA) axis occurs in response to the
organism's innate need for homeostasis. The glucocorticoids (GCs) that are released into …
organism's innate need for homeostasis. The glucocorticoids (GCs) that are released into …