Posttraumatic stress disorder-like induction elevates β-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses

NJ Justice, L Huang, JB Tian, A Cole… - Journal of …, 2015 - Soc Neuroscience
Recent studies have found that those who suffer from posttraumatic stress disorder (PTSD)
are more likely to experience dementia as they age, most often Alzheimer's disease (AD) …

Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a …

JC Carroll, M Iba, DA Bangasser… - Journal of …, 2011 - Soc Neuroscience
Because overactivation of the hypothalamic–pituitary–adrenal (HPA) axis occurs in
Alzheimer's disease (AD), dysregulation of stress neuromediators may play a mechanistic …

3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress

SM Rothman, N Herdener, S Camandola, SJ Texel… - Neurobiology of …, 2012 - Elsevier
Chronic stress may be a risk factor for developing Alzheimer's disease (AD), but most
studies of the effects of stress in models of AD utilize acute adverse stressors of …

Central CRF system perturbation in an Alzheimer's disease knockin mouse model

Q Guo, H Zheng, NJ Justice - Neurobiology of aging, 2012 - Elsevier
Alzheimer's disease (AD) is often accompanied by changes in mood as well as increases in
circulating cortisol levels, suggesting that regulation of the stress responsive hypothalamic …

Targeting psychologic stress signaling pathways in Alzheimer's disease

HS Futch, CL Croft, VQ Truong, EG Krause… - Molecular …, 2017 - Springer
Alzheimer's Disease (AD) is the most prevalent progressive neurodegenerative disease; to
date, no AD therapy has proven effective in delaying or preventing the disease course. In the …

Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model

L Hoeijmakers, SR Ruigrok, A Amelianchik… - Brain, behavior, and …, 2017 - Elsevier
Exposure to stress during the sensitive period of early-life increases the risk to develop
cognitive impairments and psychopathology later in life. In addition, early-life stress (ES) …

Stress reactivity after traumatic brain injury: implications for comorbid post-traumatic stress disorder

AN Hoffman, AN Taylor - Behavioural pharmacology, 2019 - journals.lww.com
Most people have or will experience traumatic stress at some time over the lifespan, but only
a subset of traumatized individuals develop post-traumatic stress disorder (PTSD). Clinical …

Susceptibility to PTSD-like behavior is mediated by corticotropin-releasing factor receptor type 2 levels in the bed nucleus of the stria terminalis

M Lebow, A Neufeld-Cohen, Y Kuperman… - Journal of …, 2012 - Soc Neuroscience
Posttraumatic stress disorder (PTSD) is a debilitating disease, which affects 8–10% of the
population exposed to traumatic events. The factors that make certain individuals …

Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease

YB Joshi, J Chu, D Praticò - Journal of Alzheimer's Disease, 2012 - content.iospress.com
Several studies have linked stress with Alzheimer's disease (AD) vulnerability; however, the
mechanism remains to be fully elucidated. In the current paper, we investigated the role of …

3xTg-AD mice exhibit an activated central stress axis during early-stage pathology

EK Hebda-Bauer, TA Simmons, A Sugg… - Journal of …, 2013 - content.iospress.com
Activation of the hypothalamic-pituitary-adrenal (HPA) axis occurs in response to the
organism's innate need for homeostasis. The glucocorticoids (GCs) that are released into …