Manganese porphyrin and radiotherapy improves local tumor response and overall survival in orthotopic murine mammary carcinoma models
MK Boss, RE Oberley-Deegan… - Radiation …, 2021 - meridian.allenpress.com
Novel synthetic compounds, known as manganese porphyrins (MnPs), have been designed
to shift the redox status of both normal cells and cancer cells. When MnPs are coupled with …
to shift the redox status of both normal cells and cancer cells. When MnPs are coupled with …
Single-Cell Profiling Reveals Immune-Based Mechanisms Underlying Tumor Radiosensitization by a Novel Mn Porphyrin Clinical Candidate, MnTnBuOE-2-PyP5+ …
SU Noh, J Lim, SW Shin, Y Kim, WY Park… - Antioxidants, 2024 - mdpi.com
Manganese porphyrins reportedly exhibit synergic effects when combined with irradiation.
However, an in-depth understanding of intratumoral heterogeneity and immune pathways …
However, an in-depth understanding of intratumoral heterogeneity and immune pathways …
Mechanism of the antitumor and radiosensitizing effects of a manganese porphyrin, MnHex-2-PyP
SW Shin, C Choi, GH Lee, A Son, SH Kim… - Antioxidants & redox …, 2017 - liebertpub.com
Abstract Aims: Cationic manganese (Mn)-substituted N-pyridylporphyrin-based potent
mimics of the family of superoxide dismutases (SODs) protect normal tissues from injury …
mimics of the family of superoxide dismutases (SODs) protect normal tissues from injury …
Mechanisms by which manganese porphyrins affect signaling in cancer cells
RE Oberley-Deegan, JD Crapo - Redox-Active Therapeutics, 2016 - Springer
This chapter explores the role that metalloporphyrins (MnTE-2-PyP, MnTnBuOE-2-PyP, and
MnTnHex-2-PyP) play in cancer growth and progression. This review focuses on the effect …
MnTnHex-2-PyP) play in cancer growth and progression. This review focuses on the effect …
Anticancer action of Mn porphyrins in head and neck cancer
KA Ashcraft, MW Dewhirst - Redox-Active Therapeutics, 2016 - Springer
Manganese porphyrins have been successfully used preclinically as adjuvant therapies to
radiotherapy and/or chemotherapy for tumors of multiple histologies, including brain, breast …
radiotherapy and/or chemotherapy for tumors of multiple histologies, including brain, breast …
The addition of manganese porphyrins during radiation inhibits prostate cancer growth and simultaneously protects normal prostate tissue from radiation damage
Radiation therapy is commonly used for prostate cancer treatment; however, normal tissues
can be damaged from the reactive oxygen species (ROS) produced by radiation. In separate …
can be damaged from the reactive oxygen species (ROS) produced by radiation. In separate …
Cationic Mn porphyrins change their action from anti-to pro-oxidative in the presence of cellular reductants. Relevance to understanding beneficial therapeutic effects …
Sažetak Historically cationic Mn (III) N-alkylpyridylporphyrins (MnTalkyl-2 (or 3) PyP5+) have
been regarded as the most powerful SOD mimics/antioxidants. During dismutation process …
been regarded as the most powerful SOD mimics/antioxidants. During dismutation process …
Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model
DS Gridley, AY Makinde, X Luo, A Rizvi… - Anticancer …, 2007 - ar.iiarjournals.org
Background: Antioxidants have the potential to protect normal tissues against radiation-
induced damage, but must not protect tumor cells during radiotherapy. The major objectives …
induced damage, but must not protect tumor cells during radiotherapy. The major objectives …
Mn porphyrin-based redox-active drugs: differential effects as cancer therapeutics and protectors of normal tissue against oxidative injury
I Batinic-Haberle, A Tovmasyan… - Antioxidants & redox …, 2018 - liebertpub.com
Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …
Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities
I Batinic-Haberle, I Spasojevic, HM Tse, A Tovmasyan… - Amino acids, 2012 - Springer
The most efficacious Mn (III) porphyrinic (MnPs) scavengers of reactive species have
positive charges close to the Mn site, whereby they afford thermodynamic and electrostatic …
positive charges close to the Mn site, whereby they afford thermodynamic and electrostatic …