The reactive dicarbonyl methylglyoxal (MG) behaves as a pro-oxidant agent, causing redox
dysfunction and cell death by different mechanisms in mammalian cells. MG is also a …

The C-glucosyl flavone isoorientin (ISO) is obtained by humans from the diet and exhibits
several cytoprotective effects, as demonstrated in different experimental models. However, it …

Abstract Pinocembrin (PB; 5, 7-dihydroxyflavanone) is found in propolis and exhibits
antioxidant activity in several experimental models. The antioxidant capacity of PB is …

Mitochondrial dysfunction is part of the mechanism of several human diseases. This
negative circumstance may be induced by certain toxicants, as methylglyoxal (MG). MG is a …

Disruption of the mitochondrial function has been associated with redox impairment and
triggering of cell death in nucleated human cells, as observed in several diseases. The …

Methylglyoxal (MG) is an endogenously produced toxicant that induces mitochondrial
dysfunction leading to impaired redox biology homeostasis, bioenergetics collapse, and cell …

Methylglyoxal (MG) is a reactive dicarbonyl presenting both endogenous (eg glycolysis) and
exogenous (eg food cooking) sources. MG induces neurotoxicity, at least in part, by affecting …

Methylglyoxal (MG) is a dicarbonyl molecule exhibiting high reactivity and is a major
responsible for glycation in human cells. Accumulation of MG is seen in certain diseases …

Advanced glycation end products (AGEs) and methylglyoxal (MG), an important intermediate
in AGEs synthesis, are thought to contribute to protein aging and to the pathogenesis of age …

Ethnopharmacological relevance The rate of production of reactive oxygen species (ROS) is
determined by mitochondrial metabolic rate. In turn, excessive ROS damage mitochondrial …