Background and Aims: A hallmark of inflammatory bowel disease [IBD] is chronic
inflammation, which leads to excessive extracellular matrix [ECM] remodelling and release …

Background Increased protease activity is a key pathological feature of inflammatory bowel
disease (IBD). However, the differences in extracellular matrix remodelling (ECM) in Crohn's …

Background Misbalances in extracellular matrix turnover are key factors in the development
of stricturing (Montreal B2) and penetrating (Montreal B3) Crohn's disease. Aim To …

Extracellular matrix (ECM) homeostasis is highly affected in active inflammatory bowel
disease (IBD). The aim of the study was to investigate serological biomarkers of type III, IV …

Genetic research has shaped the inflammatory bowel disease (IBD) landscape identifying
nearly two hundred risk loci. Nonetheless, the identified variants rendered only a partial …

Purpose Although Crohn's colitis (CC) and ulcerative colitis (UC) share several clinical
features, they have different causes, mechanisms of tissue damage, and treatment options …

Background As accessible diagnostic approaches fail to differentiate between ulcerative
colitis (UC) and Crohn's colitis (CC) in one-third of patients with predominantly colonic …

Introduction Crohn's disease (CD) is a complex disease, and assessing activity is
challenging due to pathobiologic process eg ECM remodeling, mucosal damage, and …

Background Increased collagen remodelling is a key pathophysiological component
underlying intestinal stricture and fistula development in Crohn's disease (CD). Aims To …

Background and aims Immunoregulatory properties of cytokines may contribute to
pathological immune reactions in inflammatory bowel disease. There is an urgent need for a …