Most immunosuppressive drugs have a narrow therapeutic index and large interpatient
variabilities in their pharmacokinetic and pharmacodynamic profiles. Identification of …

Among the immunosuppressive drugs currently used in solid-organ transplantation, the
calcineurin inhibitors cyclosporine and tacrolimus, and the mammalian target of rapamycin …

With the use of powerful immunosuppressive drugs, organ transplantation has become the
treatment of choice for many cases of end-stage chronic organ failure. The calcineurin …

Tacrolimus is a commonly used immunosuppressant after kidney transplantation. It has a
narrow therapeutic range and demonstrates wide interindividual variability in …

Summary Background: Calcineurin inhibitor (cyclosporine, CsA) and mTOR inhibitors
(sirolimus, SRL)–immunosuppressants used to prevent allograft rejection after renal …

Pharmacogenetics holds the potential to allow individualized dosing of immunosuppressive
agents to optimize their therapeutic effect while minimizing adverse effects. As more …

Cyclosporine, everolimus, and tacrolimus are the cornerstone of immunosuppressive
therapy in renal transplantation. These drugs are characterized by narrow therapeutic …

The immunosuppressive drugs used in solid-organ transplantation are potent and toxic
agents with narrow therapeutic ranges. Underdosing is associated with immunological …

Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs characterized by a
narrow therapeutic range and high pharmacokinetic variability. The effect of polymorphisms …

Objective The immunosuppressive drug tacrolimus requires strict therapeutic monitoring due
to its narrow therapeutic index and great inter-individual variability. Cytochrome P450 3A4 …