Older adults, the fastest growing population, represent almost 50% of all users of direct oral
anticoagulants (DOACs). Unfortunately, we have very little relevant pharmacological and …

Background: Direct oral anticoagulants (DOACs) provide patients with attractive options for
anticoagulation in atrial fibrillation (AF). However, dosing these agents in the elderly can be …

Balancing stroke prevention and risk of bleeding in patients with atrial fibrillation (AF) is
challenging. Direct oral anticoagulants (DOACs) are by now considered standard of care for …

Background Although a growing number of very elderly patients with atrial fibrillation (AF),
multiple conditions, and polypharmacy receive direct oral anticoagulants (DOACs), few …

One of the most important advantages of direct oral anticoagulants (DOACs) over warfarin is
that DOACs can be given in fixed doses without routine coagulation monitoring, which …

Importance The development of an optimal stroke prevention strategy, including the use of
oral anticoagulant (OAC) therapy, is particularly important for patients with atrial fibrillation …

Background—Evidence regarding the use of direct oral anticoagulants (DOACs) in the
elderly, particularly bleeding risks, is unclear despite the presence of greater comorbidities …

This study aims to provide real-world data about starting-dose of NOACs and dose-
adjustment in patients with atrial fibrillation (AF). In fact, even if new oral anticoagulation …

Background: Direct oral anticoagulants (DOACs) have been widely used in patients with
atrial fibrillation (AF) for antithrombotic prophylaxis, which were shown to have a favorable …

Non-vitamin K antagonist oral anticoagulants (NOACs) have substantially improved
anticoagulation. However, data on NOAC use among elderly patients are scarce. We sought …