Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets

K Thapa, H Khan, TG Singh, A Kaur - Journal of Molecular Neuroscience, 2021 - Springer
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary
injury mechanisms. Primary injury causes local brain damage, while secondary damage …

Traumatic brain injury pathophysiology and treatments: early, intermediate, and late phases post-injury

H Algattas, JH Huang - International journal of molecular sciences, 2013 - mdpi.com
Traumatic Brain Injury (TBI) affects a large proportion and extensive array of individuals in
the population. While precise pathological mechanisms are lacking, the growing base of …

Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

[HTML][HTML] Traumatic brain injuries: pathophysiology and potential therapeutic targets

SY Ng, AYW Lee - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics

ML Pearn, IR Niesman, J Egawa, A Sawada… - Cellular and molecular …, 2017 - Springer
Traumatic brain injury (TBI) is one of the leading causes of death of young people in the
developed world. In the United States alone, 1.7 million traumatic events occur annually …

Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury

TMJC Andriessen, B Jacobs… - Journal of cellular and …, 2010 - Wiley Online Library
Introduction• Classifying TBI‐Clinical injury severity‐Focal injury or diffuse injury• Clinical
characteristics‐Coma, confusion and subacute impairments‐Imaging TBI‐Focal and diffuse …

Pathophysiology of traumatic brain injury

AG Mustafa, OA Alshboul - Neurosciences Journal, 2013 - nsj.org.sa
Traumatic brain injury (TBI) is considered an epidemic that continues to compromise the
welfare of humankind. Despite the extensive efforts invested in countering this clinical health …

A review of the molecular mechanisms of traumatic brain injury

AA Ladak, SA Enam, MT Ibrahim - World neurosurgery, 2019 - Elsevier
Traumatic brain injury (TBI) refers to any insult to the brain resulting in primary (direct) and
secondary (indirect) damage to the brain parenchyma. Secondary damage is often linked to …

Pharmacology of traumatic brain injury: where is the “golden bullet”?

K Beauchamp, H Mutlak, WR Smith, E Shohami… - Molecular …, 2008 - Springer
Traumatic brain injury (TBI) represents a major health care problem and a significant
socioeconomic challenge worldwide. In the United States alone, approximately 1.5 million …

Neuroprotective strategies for traumatic brain injury: improving clinical translation

SV Kabadi, AI Faden - International journal of molecular sciences, 2014 - mdpi.com
Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to
delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating …