To delineate the metabolic fate of thyroid hormone in prolonged critically ill rabbits, we
investigated the impact of two dose regimes of thyroid hormone on plasma 3, 3 …

Background: The low plasma triiodothyronine (T3) observed during prolonged critical illness
can be explained in part by suppressed hepatic deiodinase type I (D1) and increased D3 …

Introduction: Marked changes in peripheral thyroid hormone metabolism occur in critical
illness, resulting in low serum T3 and high rT3 levels. In this study, we investigated whether …

Context: Pronounced alterations in serum thyroid hormone levels occur during critical
illness. T3 decreases and rT3 increases, the magnitudes of which are related to the severity …

Critical illness is often associated with reduced TSH and thyroid hormone secretion as well
as marked changes in peripheral thyroid hormone metabolism, resulting in low serum T3 …

A randomized prospective study was done to assess the response of hypothyroxinemic
patients with severe nonthyroidal illnesses to T4 therapy. Patients admitted to a medical …

Acutely ill patients typically present with low circulating T3 and increased reverse T3. When
illness is severe and prolonged, also pulsatile TSH secretion and circulating T4 levels are …

Introduction and Methods: Critical illness is associated with reduced TSH and thyroid
hormone secretion, and with changes in peripheral thyroid hormone metabolism, resulting in …

In the last decade several rodent models of NTIS have been established to unravel the
mechanisms behind NTIS. For instance, acute inflammation can be induced in rats and mice …

The imposition of a stress, such as systemic nonthyroidal illness (NTI) or caloric deprivation
in euthyroid humans, produces characteristic alterations in serum thyroid hormone indices …