Little is known about the kinetics and metabolism of thyroid hormones in the hypothyroid
state. To investigate these factors, we developed a reliable method for measurement of …

In severely ill patients of an intensive care unit overt peripheral thyroid hormone deficiency
was noted in 22 of 33 subjects. The TRH-test was performed in 7 of these 22 patients and …

Thyroid hormones are indispensable for normal growth, development and metabolism of
virtually every cell and organ (1, 2). The secretion of thyroid hormone is regulated by the …

The metabolism of 3, 3', 5'-triiodothyronine (rT3), 3, 3'-5-triiodothyronine (T3) and 3, 3'-
diiodothyronine (3, 3'-T2) by isolated rat hepatocytes in primary culture was studied by …

Previous studies have suggested that T3 metabolism relies more on nondeiodinative
conjugation than on direct deiodinative degradation for its disposal in man. To better define …

Abstract A 48-h dopamine (DA) infusion (5–7.5 fig⁄ kgmin) given to six healthy euthyroid
males resulted in a suppression of thyroidal iodine release and serum TSH by 44% 3%(P< …

In severe illness, profound changes occur in the hypothalamic-pituitary-thyroid axis. The
observed decrease in serum concentration of both thyroid hormones and thyrotropin (TSH) …

We have recently shown that it is not possible to restore euthyroidism completely in all
tissues of thyroidectomized rats infused with T4 alone. The present study was undertaken to …

In contrast to the glucuronide conjugate, T3 sulfate (T3S) undergoes rapid deiodinative
degradation in the liver and accumulates in rats and rat hepatocyte cultures if type I …

We studied the effect of thyroid hormone administration on responsivity of murine thyroid to
exogenous thyrotropin (TSH) in order to explore the possibility that the thyroid gland might …