Edward F. Adolph distinguished lecture. Contemporary model of muscle microcirculation: gateway to function and dysfunction

DC Poole - Journal of Applied Physiology, 2019 - journals.physiology.org
This review strikes at the very heart of how the microcirculation functions to facilitate blood-
tissue oxygen, substrate, and metabolite fluxes in skeletal muscle. Contemporary evidence …

Skeletal muscle capillary function: contemporary observations and novel hypotheses

DC Poole, SW Copp, SK Ferguson… - Experimental …, 2013 - Wiley Online Library
New findings• What is the topic of this review? This review presents the paradigm shift in our
understanding of capillary structure and function that has occurred since 1920 (August …

Dynamics of muscle microcirculatory and blood–myocyte O2 flux during contractions

DC Poole, SW Copp, DM Hirai, TI Musch - Acta physiologica, 2011 - Wiley Online Library
The O2 requirements of contracting skeletal muscle may increase 100‐fold above rest. In
1919, August Krogh's brilliant insights recognized the capillary as the principal site for this …

[HTML][HTML] CrossTalk opposing view: De novo capillary recruitment in healthy muscle is not necessary to explain physiological outcomes

DC Poole - The Journal of physiology, 2014 - ncbi.nlm.nih.gov
Several thousand capillaries are small enough to fit comfortably on the period at the end of
this sentence and yet, within skeletal muscle, thousands of miles of capillaries combine to …

Capillary-mitochondrial oxygen transport in muscle: paradigm shifts

DC Poole, TI Musch - Function, 2023 - academic.oup.com
When exercising humans increase their oxygen uptake (V̇O2) 20-fold above rest the
numbers are staggering: Each minute the O2 transport system-lungs, cardiovascular, active …

August Krogh: Muscle capillary function and oxygen delivery

DC Poole, Y Kano, S Koga, TI Musch - … and Physiology Part A: Molecular & …, 2021 - Elsevier
The capillary bed constitutes the obligatory pathway for almost all oxygen (O 2) and
substrate molecules as they pass from blood to individual cells. As the largest organ, by …

Muscle Microcirculatory O2 Exchange in Health and Disease

DC Poole, TI Musch - Oxygen Transport to Tissue XXXI, 2010 - Springer
Much of our understanding of blood-muscle O 2 and substrate exchange is predicated on
the presumption that, in resting muscle, a substantial proportion of the capillary bed does not …

[HTML][HTML] Microcirculation in skeletal muscle

O Hudlicka - Muscles, ligaments and tendons journal, 2011 - ncbi.nlm.nih.gov
The role of microcirculation in skeletal muscle is to provide the supply of oxygen and various
nutrients and to remove waste products of muscle metabolism. As skeletal muscles are …

Skeletal muscle circulation

RJ Korthuis - 2011 - books.google.com
The aim of this treatise is to summarize the current understanding of the mechanisms for
blood flow control to skeletal muscle under resting conditions, how perfusion is elevated …

Regulation of blood flow in the microcirculation

SS Segal - Microcirculation, 2005 - Taylor & Francis
The regulation of blood flow has rich history of investigation and is exemplified in exercising
skeletal muscle by a concerted interaction between striated muscle fibers and their …