Focus. The key issue here is whether resting skeletal muscle is fully perfused. We will make
the case that it is not, and thus there exists a reserve of unperfused capillaries (capillary …

Skeletal muscle is highly vascularized, with perfusion being tightly regulated to meet wide-
ranging metabolic demands. For decades, the capillary supply has been explored mainly in …

Muscle contractions evoke an immediate rise in blood flow. Distribution of this hyperemia
within the capillary bed may be deterministic for muscle O2diffusing capacity and remains …

This perspective examines origins of some key ideas central to major issues to be
addressed in five subsequent mini-reviews related to Skeletal and Cardiac Muscle Blood …

Skeletal muscle is highly irrigated by blood vessels. Beyond oxygen and nutrient supply,
new vessel functions have been identified. This review presents vessel microanatomy and …

An adequate supply of oxygen is essential for the normal function of all cells. Because
skeletal muscle cells have the ability to vary their oxygen demand by over an order of …

The age-related reduction in exercise capacity is associated with a reduction in cardiac
output and maximal oxygen consumption (Vo 2max). The loss of muscle mass explains a …

The role of capillaries is to serve as the interface for delivery of oxygen and removal of
metabolites to/from tissues. During the past decade there has been a proliferation of studies …

The matching of capillary blood flow to metabolic rate of the cells within organs and tissues
is a critical microvascular function which ensures appropriate delivery of hormones and …