In humans at exercise onset, intramuscular phosphocreatine decreases immediately,
whereas muscle oxygen (O 2) uptake seems to rise after a delay of up to 15 s which is …

In this issue of European Journal of Applied Physiology, Taylor et al. show that the
angiogenic potential of one 120 s bout of continuous all-out cycling is similar to the …

Key points The capillary module, consisting of parallel capillaries from arteriole to venule, is
classically considered as the building block of complex capillary networks. In skeletal …

Microcirculatory red blood cell (RBC) hemodynamics are impaired within skeletal muscle of
Type I diabetic rats (Kindig CA, Sexton WL, Fedde MR, and Poole DC. Respir Physiol 111 …

Key points Oxygen pressure gradients across the microvascular walls are essential for
oxygen diffusion from blood to tissue cells. At any given flux, the magnitude of these …

Skeletal muscle blood flow is reduced and O2 extraction is increased at rest in chronic heart
failure (CHF). Knowledge of red blood cell (RBC) flow distribution within the capillary …

Microvascular structure and function are key aspects of tissue and organ health. At
approximately 40% of total body mass, skeletal muscle contains more microvessels than any …

The notion that a substantial proportion of capillaries do not contain moving red blood cells
(RBCs) in muscle at rest but are “recruited,” ie, begin flowing with RBCs during contractions …

Capillaries, which are the smallest and most abundant type of blood vessel, form the primary
site of gas, nutrient, and waste transfer between the vascular and tissue compartments …

Oxygen is transferred from air to mitochondria in sequential steps by means of diffusion and
convection. The theoretical ceiling for whole body aerobic uptake may be determined by any …