A child is not a mini adult. They differ from adults in terms of weight, shape, anatomical size
and major body systems such as cardiovascular and respiratory as well as psychologically …

Anesthesiology Clin 35 (2017) e73–e94 http://dx. doi. org/10.1016/j. anclin. 2017.01. 012
anesthesiology. theclinics. com 1932-2275/17/© 2017 Elsevier Inc. All rights reserved …

Evolution of anaesthesia has been largely helped by progress of evidence-based medicine.
In spite of many advancements in anaesthesia techniques and availability of newer and …

Anaesthesia for neonates is a composite of good knowledge of neonatal and transitional
physiology combined with skill in airway maintenance and vascular access. When the …

Abstract Anaesthesia dosing in infants (0–2 years) should be based on pharmacokinetic–
pharmacodynamic considerations and adverse effects profiles. Disease processes and …

Pharmacokinetics and pharmacodynamics of drugs and inhalational agents used in
anaesthesia have been studied extensively. However, it is only recently that some of the …

Paediatric patients include neonates (less than 30 days of age), infants (1-12 months of
age), and children (1-12 years of age) who are not merely small adults. Their successful and …

Perioperative anxiety in children has often been associated with diverse implications like
separation anxiety, emergence delirium, enhanced analgesic requirements and subsequent …

Introduction: The target concentration strategy uses PKPD information for dose
determination. Models have also quantified exposure-response relationships, improved …

Effective and safe drug administration in neonates should be based on integrated
knowledge on the evolving physiological characteristics of the infant who will receive the …