The mortality rate for septic patients with acute renal failure is approximately doubled
compared with patients with sepsis alone. Unfortunately, the treatment for sepsis-induced …

Lipopolysaccharide (LPS)-induced renal oxidant injury and the role of nitric oxide (NO) were
evaluated using the inducible nitric oxide synthase (iNOS) inhibitor l-iminoethyl-lysine (l …

Excess NO generation plays a major role in the hypotension and systemic vasodilatation
characteristic of sepsis. Yet the kidney response to sepsis is characterized by …

Sepsis-induced acute kidney injury (AKI) is a complex disease characterized by generation
of inducible nitric oxide synthase (iNOS)–derived reactive nitrogen species (RNS) by the …

Background The regulation of renal hemodynamics is closely related to the L-arginine (L-
Arg)/nitric oxide (NO) pathway. NO-metabolized from L-Arg-is capable of improving renal …

Acute kidney injury (AKI) remains a frequent and serious complication of human sepsis that
contributes significantly to mortality. For better understanding of the development of AKI …

Previous studies have demonstrated that inducible nitric oxide synthase (iNOS) plays a key
pathophysiologic role during sepsis. The present study was designed to delineate the …

Nitric oxide (NO), generated by inducible nitric oxide synthase (NOS) following
lipopolysaccharide (LPS) administration, produces renal failure through autoinhibition of …

Nitric oxide (NO) is postulated to play a key role in the pathophysiology of renal failure in
sepsis. Whether the renal effects of increased NO are beneficial or harmful remains unclear …

SUMMARY 1 The role of nitric oxide synthases (NOS) and the nitric oxide (NO) substrate l‐
arginine in renal ischaemia–reperfusion (I/R) has been studied extensively. However, the …