Liver stiffness hinders normalization of systemic inflammation and endothelial activation after hepatitis C virus (HCV) eradication in HIV/HCV coinfected patients

B Álvarez, C Restrepo, M García, MA Navarrete-Muñoz… - Vaccines, 2020 - mdpi.com
Systemic inflammation, endothelial dysfunction and coagulopathy are of high clinical
relevance in the management of people living with HIV (PLWH), and even more in patients …

Elevated liver stiffness is linked to increased biomarkers of inflammation and immune activation in HIV/hepatitis C virus-coinfected patients

LM Medrano, P Garcia-Broncano, J Berenguer… - Aids, 2018 - journals.lww.com
Objectives: Immune dysregulation is a hallmark of HIV and hepatitis C virus (HCV)
infections. We aimed to evaluate the relationship between liver stiffness measurement (LSM) …

Both HCV infection and elevated liver stiffness significantly impacts on several parameters of T-cells homeostasis in HIV-infected patients

C Restrepo, B Álvarez, JL Valencia, M García… - Journal of Clinical …, 2020 - mdpi.com
(1) Background: The role of hepatitis C virus (HCV) co-infection on the T-cell homeostasis
disturbances in human immunodeficiency virus (HIV)-infected patients as well as its …

Modifications of liver stiffness and CXCL4, TGF-β1 and HGF are similar in HCV-and HIV/HCV-infected patients after DAAs

M Márquez-Coello, A Arizcorreta… - Scientific Reports, 2021 - nature.com
The objective of this work was to identify predictive factors of fibrosis regression after direct
antiviral agents (DAAs) in HCV-monoinfected and HIV/HCV-coinfected patients. This was a …

Liver stiffness regression after successful Hepatitis C treatment is independent of HIV coinfection

JJ Malin, C Boesecke, C Schwarze‐Zander… - HIV …, 2019 - Wiley Online Library
Objectives The aim of the study was to assess the regression of liver stiffness after
successful direct‐acting antiviral (DAA) treatment in patients with hepatitis C virus (HCV) …

Liver stiffness at the time of sustained virological response predicts the clinical outcome in people living with human immunodeficiency virus and hepatitis C virus with …

A Corma-Gómez, J Macías, F Téllez… - Clinical Infectious …, 2020 - academic.oup.com
Background Some people living with hepatitis C virus (HCV) with sustained virological
response (SVR) develop hepatic complications. Liver stiffness (LS) predicts clinical outcome …

Liver stiffness reduction and serum fibrosis score improvement in HIV/hepatitis C virus‐coinfected patients treated with direct‐acting antivirals

G Fabbri, I Mastrorosa, A Vergori, L Timelli… - HIV …, 2018 - Wiley Online Library
Objectives Only a few studies have addressed liver stiffness dynamics after hepatitis C virus
(HCV) treatment in patients with HIV/HCV coinfection. The aim was to evaluate the variation …

Regression of liver stiffness after sustained hepatitis C virus (HCV) virological responses among HIV/HCV-coinfected patients

ACOH Cohort - AIDS (London, England), 2015 - pubmed.ncbi.nlm.nih.gov
Objective We assessed the impact of a sustained virological response (SVR) on liver
stiffness among HIV/hepatitis C virus (HCV)-coinfected patients enrolled in the ANRS CO13 …

Dysregulation of the immune system in HIV/HCV-coinfected patients according to liver stiffness status

P Garcia-Broncano, LM Medrano, J Berenguer… - Cells, 2018 - mdpi.com
Background: Advanced cirrhosis is related to alterations in immunity. We aimed to evaluate
the levels of peripheral CD4+ T cells (Tregs) and plasma cytokine in patients coinfected with …

Successful HCV therapy reduces liver disease severity and inflammation biomarkers in HIV/HCV-coinfected patients with advanced cirrhosis: a cohort study

LM Medrano, J Berenguer, S Salgüero… - Frontiers in …, 2021 - frontiersin.org
Background: Eradication of hepatitis C virus (HCV) promotes an improvement in liver
disease and the deactivation of the immune system. Here, we aimed to evaluate the …