Intravenous norepinephrine (NE) is utilized commonly in critical care for cardiovascular
support. NE's impact on cerebrovasculature is unclear and may carry important implications …

Intravenous phenylephrine (PE) is utilized commonly in critical care for cardiovascular
support. Its impact on the cerebrovasculature is unclear and its use may have important …

Ischemic stroke is the leading cause of morbidity and mortality with a significant health
burden worldwide and few treatment options. Among the short-and long-term effects of …

Background Vasopressor agents are commonly used to increase mean arterial pressure
(MAP) in order to secure a pressure gradient to perfuse vital organs. The influence of …

Objective: Traumatic brain injury is frequently accompanied by a systemic inflammatory
response. Systemic inflammation was associated with cerebral hyperperfusion uncoupled to …

Background and objective Despite multiple interventions, mortality due to severe traumatic
brain injury (sTBI) within mature Trauma Systems has remained unchanged over the last …

Abstract α-Adrenergic drugs improve cerebral blood flow (CBF) during cardiopulmonary
resuscitation (CPR), in part, by reversing carotid artery collapse and by shunting blood from …

Norepinephrine (NE; also known as noradrenaline) is the body's primary adrenergic
neurotransmitter which belongs to the catecholamine family. Norepinephrine has …

Objectives Reduction of cerebral perfusion during the early phase after traumatic brain injury
is followed by a later phase of normal to increased perfusion. Thus, pharmacologically …

Septic shock, systemic inflammation and pharmacological vasodilatation are often
complicated by systemic hypotension despite aggressive fluid resuscitation and an …