ERK1 and ERK2 (ERKs), two extracellular regulated kinases (ERK1/2), are evolutionary-
conserved and ubiquitous serine-threonine kinases involved in regulating cell signalling in …

ERK1 and ERK2 are key protein kinases that contribute to the Ras-Raf-MEK-ERK MAP
kinase signalling module. This pathway participates in the control of numerous processes …

Abstract The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is de-regulated in a
variety of cancers due to mutations in receptor tyrosine kinases (RTKs), negative regulators …

Mitogen‑activated protein kinase (MAPK) cascades are key signalling pathways that
regulate a wide variety of cellular processes, including proliferation, differentiation …

Molecularly tailored therapies have opened a new era, chronic myeloid leukemia being the
ideal example, in the treatment of cancer. However, available therapeutic options are still …

The MAP kinase signaling cascade Ras/Raf/MEK/ERK has been involved in a large variety
of cellular and physiological processes that are crucial for life. Many pathological situations …

Abstract The RAS/RAF/MEK pathway is activated in more than 30% of human cancers, most
commonly via mutation in the K-ras oncogene and also via mutations in BRAF. Several …

The extracellular-regulated kinases ERK1 and ERK2 are evolutionarily conserved,
ubiquitous serine–threonine kinases that are involved in regulating cellular signaling in both …

Background The mitogen-activated protein (MAP) kinases p44 ERK1 and p42 ERK2 are
crucial components of the regulatory machinery underlying normal and malignant cell …

The name extracellular signal-regulated kinase (ERK) was first used for a cell cycle
regulating Ser/Thr protein kinase cloned in mammalian cells [1], which was termed ERK1 …