[HTML][HTML] TRPV1: a target for rational drug design
V Carnevale, T Rohacs - Pharmaceuticals, 2016 - mdpi.com
Transient Receptor Potential Vanilloid 1 (TRPV1) is a non-selective, Ca2+ permeable cation
channel activated by noxious heat, and chemical ligands, such as capsaicin and …
channel activated by noxious heat, and chemical ligands, such as capsaicin and …
Transient receptor potential vanilloid type 1 antagonists: a patent review (2011–2014)
Introduction: Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation
channel that can be activated by noxious heat, low pH and vanilloid compounds such as …
channel that can be activated by noxious heat, low pH and vanilloid compounds such as …
TRPV1: a target for next generation analgesics
LS Premkumar, P Sikand - Current neuropharmacology, 2008 - ingentaconnect.com
Transient Receptor Potential Vanilloid 1 (TRPV1) is a Ca2+ permeant non-selective cation
channel expressed in a subpopulation of primary afferent neurons. TRPV1 is activated by …
channel expressed in a subpopulation of primary afferent neurons. TRPV1 is activated by …
Discovery of novel 6, 6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists
CA Blum, T Caldwell, X Zheng… - Journal of medicinal …, 2010 - ACS Publications
The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a
nonselective cation channel that can be activated by a wide range of noxious stimuli …
nonselective cation channel that can be activated by a wide range of noxious stimuli …
Transient receptor potential vanilloid-1 antagonists: a survey of recent patent literature
EA Voight, ME Kort - Expert Opinion on Therapeutic Patents, 2010 - Taylor & Francis
Importance of the field: Transient receptor potential vanilloid-1 (TRPV1, vanilloid receptor-1)
is a nonspecific cation channel that can be activated by multiple endogenous stimuli and by …
is a nonspecific cation channel that can be activated by multiple endogenous stimuli and by …
TRPV1-targeted drugs in development for human pain conditions
The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …
Progress in the development of TRPV1 small-molecule antagonists: Novel Strategies for pain management
K Zhu, L Wang, TT Liao, W Li, J Zhou, Y You… - European journal of …, 2023 - Elsevier
Transient receptor potential vanilloid 1 (TRPV1) channels are widely distributed in sensory
nerve endings, the central nervous system, and other tissues, functioning as ion channel …
nerve endings, the central nervous system, and other tissues, functioning as ion channel …
Medicinal chemistry, pharmacology, and clinical implications of TRPV1 receptor antagonists
M Aghazadeh Tabrizi, PG Baraldi… - Medicinal research …, 2017 - Wiley Online Library
Transient receptor potential vanilloid 1 (TRPV1) is an ion channel expressed on sensory
neurons triggering an influx of cations. TRPV1 receptors function as homotetramers …
neurons triggering an influx of cations. TRPV1 receptors function as homotetramers …
[PDF][PDF] Beyond hot and spicy: TRPV channels and their pharmacological modulation
G Seebohm, JA Schreiber - Cell Physiol Biochem, 2021 - articles.cellphysiolbiochem.com
Transient receptor potential vanilloid (TRPV) channels are part of the TRP channel
superfamily and named after the first identified member TRPV1, that is sensitive to the …
superfamily and named after the first identified member TRPV1, that is sensitive to the …
Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists
N Tamayo, H Liao, MM Stec, X Wang… - Journal of medicinal …, 2008 - ACS Publications
Transient receptor potential vanilloid 1 (TRPV1) channel antagonists may have clinical utility
for the treatment of chronic nociceptive and neuropathic pain. We recently advanced a …
for the treatment of chronic nociceptive and neuropathic pain. We recently advanced a …