The methylation pathway, which consists of two metabolic cycles of nutrients, ie, the
methionine and folate cycles, generates S‐adenosylmethionine, the methyl donor for the …

Transcript abundance of histone variants, modifiers of histone and DNA in bovine in vivo
oocytes and embryos were measured as mean transcripts per million (TPM). Six of 14 …

The involvement of specific nutrients in epigenetic gene regulation is a possible mechanism
underlying nutrition-directed phenotypic alteration. However, the involvement of nutrients in …

Abstract Development from separate parental germ cells through fertilization and
proceeding to a fully functioning adult animal occurs through an intricate program of …

DNA methylation undergoes drastic fluctuation during early mammalian embryogenesis.
The dynamics of global DNA methylation in bovine embryos, however, have mostly been …

Fertilization in bovines causes profound changes in the epigenetic profile that affect both
DNA methylation patterns and posttranslational histone modifications. These dynamic …

In mouse and most other mammalian species, the paternal and maternal genomes undergo
parent-specific epigenetic reprogramming during preimplantation development. The …

The embryonic pattern of global DNA methylation is first established in the inner cell mass
(ICM) of the mouse blastocyst. The methyl donor S‐adenosylmethionine (SAM) is produced …

Unlike the mouse embryo, where loss of DNA methylation in the embryonic nucleus leaves
cleavage stage embryos globally hypomethylated, sheep preimplantation embryos retain …

There is species divergence in control of DNA methylation during preimplantation
development. The exact pattern of methylation in the bovine embryo has not been …