Regulation of the mRNA-binding protein HuR by posttranslational modification: spotlight on phosphorylation

W Eberhardt, A Doller… - Current Protein and …, 2012 - ingentaconnect.com
The ubiquitous mRNA-binding protein human antigen R (HuR) and its neuronal relatives
(HuB, HuC, HuD) participate in the post-transcriptional regulation of many AU-rich element …

Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sites

PJ Uren, SC Burns, J Ruan, KK Singh, AD Smith… - Journal of Biological …, 2011 - ASBMB
The ubiquitously expressed RNA-binding protein Hu antigen R (HuR) or ELAVL1 is
implicated in a variety of biological processes as well as being linked with a number of …

Oligomeric transition and dynamics of RNA binding by the HuR RRM1 domain in solution

C Lixa, A Mujo, MTQ de Magalhães… - Journal of Biomolecular …, 2018 - Springer
Human antigen R (HuR) functions as a major post-transcriptional regulator of gene
expression through its RNA-binding activity. HuR is composed by three RNA recognition …

The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets

RM Scheiba, AI de Opakua, A Díaz-Quintana… - RNA biology, 2014 - Taylor & Francis
Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which
bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal …

[HTML][HTML] Overexpression of HuR, a nuclear–cytoplasmic shuttling protein, increases the in vivo stability of ARE‐containing mRNAs

XC Fan, JA Steitz - The EMBO journal, 1998 - embopress.org
The messenger RNAs of many proto‐oncogenes, cytokines and lymphokines are targeted
for rapid degradation through AU‐rich elements (AREs) located in their 3′ untranslated …

HuR thermal stability is dependent on domain binding and upon phosphorylation

RM Scheiba, Á Aroca, I Díaz-Moreno - European biophysics journal, 2012 - Springer
Human antigen R (HuR) is a multitasking RNA binding protein involved in
posttranscriptional regulation by recognizing adenine-and uracile-rich elements placed at …

The RNA binding protein HuR: a promising drug target for anticancer therapy

M Wu, CWS Tong, W Yan, KKW To… - Current cancer drug …, 2019 - ingentaconnect.com
The stability of mRNA is one of the key factors governing the regulation of eukaryotic gene
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …

Androgens regulate the binding of endogenous HuR to the AU-rich 3′ UTRs of HIF-1α and EGF mRNA

LG Sheflin, AP Zou, SW Spaulding - Biochemical and biophysical research …, 2004 - Elsevier
The 3′ UTRs of mammalian HIF-1α and EGF mRNA contain several highly conserved AU-
rich elements (ARE) known to control the turnover of labile mRNAs by binding ARE-binding …

HuR and mRNA stability

CM Brennan, JA Steitz* - Cellular and Molecular Life Sciences CMLS, 2001 - Springer
An important mechanism of posttranscriptional gene regulation in mammalian cells is the
rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in …

HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA

S Park, DG Myszka, M Yu, SJ Littler… - Molecular and cellular …, 2000 - Taylor & Francis
Human neuron-specific RNA-binding protein HuD belongs to the family of Hu proteins and
consists of two N-terminal RNA recognition motifs (RRM1 and-2), a hinge region, and a C …