Tumor hypoxia has proven to be the major bottleneck of photodynamic therapy (PDT) to
clinical transformation. Different from traditional O2 delivery approaches, here we describe …

Tumor hypoxia severely limits the therapeutic effects of photodynamic therapy (PDT).
Although many methods for oxygen generation exist, substantial safety concerns …

The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic
efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved …

Hypoxia, a quite universal feature in most solid tumors, has been considered as the
“Achilles' heel” of traditional photodynamic therapy (PDT) and substantially impairs the …

Conspectus The advent of photochemical techniques has revolutionized the landscape of
biology and medical sciences. Especially appealing in this context is photodynamic therapy …

Photodynamic therapy (PDT) has been a well‐accepted clinical treatment for malignant
tumors owing to its noninvasiveness and high spatiotemporal selectivity. However, the …

Abnormal tumor metabolism causes the hypoxic microenvironment, which greatly limits the
efficacy of photodynamic therapy (PDT). In this work, a strategy of metabolic reprogramming …

Despite the clinical potential, photodynamic therapy (PDT) relying on singlet oxygen (1O2)
generation is severely limited by tumor hypoxia and endosomal entrapment. Herein, a …

Photodynamic therapy (PDT) with an oxygen-dependent character is a noninvasive
therapeutic method for cancer treatment. However, its clinical therapeutic effect is greatly …

Conventional oxygen‐dependent photodynamic therapy (PDT) has faced severe challenges
because of the non‐specificity of most available photosensitizers (PSs) and the hypoxic …