Hypoxia of solid tumor compromises the therapeutic outcome of photodynamic therapy
(PDT) that relies on localized O2 molecules to produce highly cytotoxic singlet oxygen (1O2) …

Spatiotemporal control of singlet oxygen (1O2) release is a major challenge for
photodynamic therapy (PDT) against cancer with high therapeutic efficacy and minimum …

Enhancing the phototherapy efficacy of organic photosensitizers through molecular design
is a fascinating but challenging task. Herein, we propose a simple design strategy to first …

Hypoxia within solid tumors severely limits the efficacy of photodynamic therapy (PDT).
Biocompatible calcium peroxide nanoparticles (CaO2 NPs) have superior oxygen …

Photodynamic therapy (PDT), with its advantages of high targeting, minimally invasive, and
low toxicity side effects, has been widely used in the clinical therapy of various tumors …

Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the
tumor cells. Oxygen-consumption photodynamic therapy (PDT) suffers from the undesirable …

Many cancer treatments including photodynamic therapy (PDT) utilize reactive oxygen
species (ROS) to kill tumor cells. However, elevated antioxidant defense systems in cancer …

Given that Type-I photosensitizers (PSs) have hypoxia tolerance, developing general
approaches to prepare Type-I PSs is of great importance, but remains a challenge. Here, we …

Photosensitizer-based photodynamic therapy (PDT) can not only kill tumor cells by the
generated cytotoxic reactive oxygen species (ROS), but also trigger immunogenic cell death …

Hypoxia severely impedes photodynamic therapy (PDT) efficiency. Worse still, considerable
tumor metastasis will occur after PDT. Herein, an organic superoxide radical (O2∙−) nano …