Tooth agenesis is one of the most common developmental anomalies in humans and can
affect dental occlusion and speech pronunciation. Research has identified an association …

Tooth agenesis is one of the most common craniofacial disorders in humans. More than 350
genes have been associated with teeth development. In this study, we enrolled 60 child …

Abstract Background MSX1 (OMIM# 142983) is crucial to normal dental development, and
variants in MSX1 are associated with dental anomalies. The objective of this study was to …

Background Tooth agenesis is a common developmental dental anomaly. The aim of the
study was to identify the causal genetic mutation in a four-generation Chinese family …

The goal of this study was to identify MSX1 gene variants in multiple Chinese families with
nonsyndromic oligodontia and analyse the functional influence of these variants. Whole …

Congenital tooth agenesis is a common anomaly in humans. We investigated the etiology of
human tooth agenesis by exome analysis in Japanese patients, and found a previously …

Since MSX1 and PAX9 are linked to the pathogenesis of nonsyndromic tooth agenesis, we
performed detailed mutational analysis of these two genes sampled from Japanese patients …

Background MSX1 sequence variants have been known to cause human tooth agenesis
(TA) with or without orofacial clefts. However, their roles during the whole processes of tooth …

Oligodontia, which is the congenital absence of six or more permanent teeth, excluding the
third molars, may contribute to masticatory dysfunction, speech alteration, aesthetic …

Tooth agenesis constitutes the most common anomaly of dental development in humans. In
the majority of familial cases of hypodontia alone or in association with other anomalies, the …