Concurrent treatment of tumor recurrence and bone defects after surgical resection of
osteosarcoma remains a clinical challenge. Combination therapy based on local drug …

The inefficacy of the currently used therapies in achieving the regeneration ad integrum of
the periodontium stimulates the search for alternative approaches, such as tissue …

Herein, we have developed hybrid nanocomposites of chitosan, poly (ethylene glycol) and
nano-hydroxyapatite–zinc oxide with interconnected macroporous structures for bone tissue …

Background and Purpose The extracellular matrix (ECM) derived from bone marrow
mesenchymal stem cells (BMSCs) has been used in regenerative medicine because of its …

Periodontal regeneration is still a challenge for periodontists and tissue engineers, as it
requires the simultaneous restoration of different tissues—namely, cementum, gingiva …

In this research, the Polycaprolactone/Gelatin/Hydroxyapatite nanoparticles (PGH) scaffold
was successfully fabricated through electrospinning technique and the physical, chemical …

Regeneration of periodontal tissue remains a challenge. Under periodontitis, osteoclasts are
overactivated and bone loss occurs. We incorporated sodium alendronate (Alen), a …

Insufficient oxygen availability in tissue engineering is one of the major factors for the failure
of clinical transplantation. One potential strategy to conquer this limitation is the fabrication of …

Contaminated or infected bone defects remain serious challenges in clinical trauma and
orthopaedics, and a bone substitute with both osteoconductivity and antibacterial properties …

Limited self-regenerating capacity of human skeleton makes the reconstruction of critical
size bone defect a significant challenge for clinical practice. Aimed for regenerating bone …