Ischemic stroke (IS) is a leading cause of disability and death worldwide. IS arises from a
blocked artery in the brain that causes a lack of oxygen and nutrient supply to other brain …

Vascular mechanisms underlying the adverse effects that depression and stress-related
mental disorders have on stroke outcome are only partially understood. Identifying the …

The vascular endothelium is at the first line of the complex interface between the blood and
the brain parenchyma that conforms the blood-brain barrier (BBB). Ischemia impacts upon …

BACKGROUND: Ischemic stroke (IS) is a life-threatening condition with limited treatment
options; thus, finding the potential key genes for novel therapeutic targets is urgently …

It is important to understand the molecular mechanisms underlying neuron death following
stroke in order to develop effective neuroprotective strategies. Since studies on human …

Brain ischemia, also termed cerebral ischemia, is a condition in which there is insufficient
blood flow to the brain to meet metabolic demand, leading to tissue death (cerebral …

Vascular endothelial function is challenged during cerebral ischemia and reperfusion. The
endothelial responses are involved in inflammatory leukocyte attraction, adhesion and …

Cerebral ischemia is a major cause of morbidity and mortality worldwide, being more
prevalent in the elderly. Ischemic stroke disrupts the blood-brain barrier, triggering multiple …

Aim: In the course of ischemia reperfusion, injury/functional deterioration of the endothelium
contribute to tissue damaging process. Hypoxia-reoxygenation model has been used as in …

The genetic transcription profile of brain ischemic and reperfusion injury remains elusive. To
address this, we used an integrative analysis approach including differentially expressed …