Pathogenic mechanisms of neurodegeneration based on the phenotypic expression of progressive forms of immune-mediated neurologic disease
MC Levin, S Lee, LA Gardner, Y Shin… - Degenerative …, 2012 - Taylor & Francis
Considering there are no treatments for progressive forms of multiple sclerosis (MS), a
comprehensive understanding of the role of neurodegeneration in the pathogenesis of MS …
comprehensive understanding of the role of neurodegeneration in the pathogenesis of MS …
The immune response in multiple sclerosis
S Rodríguez Murúa, MF Farez… - Annual Review of …, 2022 - annualreviews.org
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …
disease that affects the central nervous system (CNS). MS is characterized by immune …
Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries
The immunopathology of herpes simplex virus (HSV)‐associated neuroinflammation is a
captivating and intricate field of study within the scientific community. HSV, renowned for its …
captivating and intricate field of study within the scientific community. HSV, renowned for its …
Indictment of the microglia as the villain in multiple sclerosis
S Sriram, M Rodriguez - Neurology, 1997 - AAN Enterprises
Over the past decade, considerable attention has focused on the theory that MS is an
autoimmune disease mediated by T cells specific for neural autoantigens.'s2 Infectious …
autoimmune disease mediated by T cells specific for neural autoantigens.'s2 Infectious …
Cell replacement therapies to promote remyelination in a viral model of demyelination
E Tirotta, KS Carbajal, CS Schaumburg… - Journal of …, 2010 - Elsevier
Persistent infection of the central nervous system (CNS) of mice with the neuroadapted JHM
strain of mouse hepatitis (MHV) is characterized by ongoing demyelination mediated by …
strain of mouse hepatitis (MHV) is characterized by ongoing demyelination mediated by …
Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response
Multiple sclerosis is considered a disease of complex autoimmune etiology, yet there
remains a lack of consensus as to specific immune effector mechanisms. Recent analyses of …
remains a lack of consensus as to specific immune effector mechanisms. Recent analyses of …
Viral models of multiple sclerosis: neurodegeneration and demyelination in mice infected with Theiler's virus
Multiple sclerosis (MS) is a complex inflammatory disease of unknown etiology that affects
the central nervous system (CNS) white matter, and for which no effective cure exists …
the central nervous system (CNS) white matter, and for which no effective cure exists …
Update on inflammation, neurodegeneration, and immunoregulation in multiple sclerosis: therapeutic implications
JL Bennett, O Stüve - Clinical neuropharmacology, 2009 - journals.lww.com
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease
of the central nervous system of uncertain etiology. There is consensus that a dysregulated …
of the central nervous system of uncertain etiology. There is consensus that a dysregulated …
[HTML][HTML] Differential neuro-immune patterns in two clinically relevant murine models of multiple sclerosis
KD DiSano, MR Linzey, DB Royce, AR Pachner… - Journal of …, 2019 - Springer
Background The mechanisms driving multiple sclerosis (MS), the most common cause of
non-traumatic disability in young adults, remain unknown despite extensive research …
non-traumatic disability in young adults, remain unknown despite extensive research …
Synergistic immune responses induced by endogenous retrovirus and herpesvirus antigens result in increased production of inflammatory cytokines in multiple …
T Brudek, T Christensen, HJ Hansen… - Scandinavian …, 2008 - Wiley Online Library
Human endogenous retroviruses (HERV) and herpesviruses are increasingly associated
with the pathogenesis of the neurological inflammatory disease multiple sclerosis (MS) …
with the pathogenesis of the neurological inflammatory disease multiple sclerosis (MS) …