The vagus nerve can limit inflammation via the α7 nicotinic acetylcholine receptor
(α7nAChR). Selective pharmacological stimulation of the α7nAChR may have therapeutic …

To diminish heart failure development after acute myocardial infarction (AMI), several
preclinical studies have focused on influencing the inflammatory processes in the healing …

Excessive activation of pro‐inflammatory M1 macrophages following acute myocardial
infarction (MI) aggravates adverse cardiac remodelling and heart dysfunction. There are two …

Inflammation plays a central role in stroke-induced brain injury. The alpha7 nicotinic
acetylcholine receptor (α7nAChR) can modulate immune responses in both the periphery …

Objective: To investigate the cellular mechanism that sinomenine (SIN) inhibits inflammation
in macrophages induced by LPS through α7 nicotinic acetylcholine receptor (α7nAChR) …

Previous reports have indicated that artificial stimulation of the vagus nerve reduces
systemic inflammation in experimental models of sepsis. This phenomenon is a part of a …

Objective—Cholinergic pathways of the autonomic nervous system are known to modulate
inflammation. Because atherosclerosis is a chronic inflammatory condition, we tested …

Rationale: This study was performed to gain insights into novel therapeutic approaches for
the treatment of autoimmune myocarditis. Objective: Chemical stimulation of the efferent arm …

Activation of nicotinic acetylcholine receptors (nAChRs) expressed by innate immune cells
can attenuate pro-inflammatory responses. Silent nAChR agonists, which down-modulate …

It is increasingly clear that nicotinic acetylcholine receptors (nAChRs) are involved in
immune regulation, and that their activation can protect against inflammatory diseases …