The pathogenesis of chronic inflammation, a common denominator in cardiovascular,
metabolic and systemic autoimmune diseases, is influenced by a number of genetic …

Since the discovery of oxidized phospholipids (OxPL) and their implication as modulators of
inflammation in cardiovascular disease, roles for these lipid oxidation products have been …

Biologically active oxidized phospholipids can initiate and modulate many of the cellular
events attributed to inflammation leading to atherosclerosis. Produced by enzymatic or non …

Glycerophospholipids represent a common class of lipids critically important for integrity of
cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes …

Phospholipids containing polyunsaturated fatty acids are highly prone to modification by
reactive oxygen species. They tend to undergo lipid peroxidation to form OxPLs which …

Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly
recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL …

“Wherever you get inflammation, you get oxidized phospholipids (ox-Pls),” says Joseph
Witztum, senior author of a new study published in Nature. Witztum and colleagues now …

Lipid peroxidation occurs in the context of many physiological processes but is greatly
increased in various pathological situations. A consequence of phospholipid peroxidation is …

During inflammatory processes biologically active lipid oxidation products accumulate that
modulate the inflammatory process and may determine the fate and outcome of the body's …

Long thought of as a bystander in pathophysiological processes, lipid molecules have
emerged as bioactive mediators of cardiovascular pathology. There has been accumulating …