Oxidized phospholipids: emerging lipid mediators in pathophysiology

HP Deigner, A Hermetter - Current opinion in lipidology, 2008 - journals.lww.com
Recent studies shed some light on oxidized phospholipid-induced signalling with regard to
apoptosis, gene expression and receptor-mediated events. They support the notion that the …

Oxidised phospholipids as biomarkers in human disease

M Philippova, T Resink, P Erne, V Bochkov - Swiss medical weekly, 2014 - smw.ch
Oxidised phospholipids (OxPLs) are generated from (poly) unsaturated diacyl-and alk (en)
ylacyl glycerophospholipids under conditions of oxidative stress. OxPLs exert a wide variety …

Hormetic and anti-inflammatory properties of oxidized phospholipids

C Mauerhofer, M Philippova, OV Oskolkova… - Molecular aspects of …, 2016 - Elsevier
Oxidized phospholipids are generally recognized as deleterious factors involved in disease
pathogenesis. This review summarizes the data suggesting that under certain biological …

The role of oxidized phospholipids in the development of disease

J Nie, J Yang, Y Wei, X Wei - Molecular aspects of medicine, 2020 - Elsevier
Oxidized phospholipids (OxPLs), complex mixtures of phospholipid oxidation products
generated during normal or pathological processes, are increasingly recognized to show …

How oxidized low-density lipoprotein activates inflammatory responses

JP Rhoads, AS Major - Critical Reviews™ in Immunology, 2018 - dl.begellhouse.com
Cardiovascular disease (CVD) is the number one cause of death in the United States and
worldwide. The most common cause of cardiovascular disease is atherosclerosis, or …

Oxidized lipoprotein autoimmunity: an emerging drug target in cardiovascular disease

J Nilsson, GN Fredrikson, KY Chyu… - Clinical Lipidology …, 2006 - search.proquest.com
Oxidative modification of low-density lipoprotein (LDL) in the arterial wall is believed to be
one of the most important mechanisms involved in the development of atherosclerosis. It is …

Oxidized phospholipids as triggers of inflammation in atherosclerosis

N Leitinger - Molecular nutrition & food research, 2005 - Wiley Online Library
Chronic inflammatory diseases including atherosclerosis are major causes of morbidity and
mortality worldwide. However, the factors, which trigger processes that determine the …

Oxidative modification of lipoproteins: mechanisms, role in inflammation and potential clinical applications in cardiovascular disease

S Tsimikas, YI Miller - Current pharmaceutical design, 2011 - ingentaconnect.com
Abnormalities of lipid metabolism often lead to pathologic lipid accumulation in the vessel
wall, oxidative and chronic inflammatory sequelae and the formation of atherosclerotic …

Oxidized LDL induces in vitro lymphocyte activation in antiphospholipid syndrome

R Laczik, P Szodoray, K Veres, G Lakos, S Sipka… - …, 2010 - Taylor & Francis
Oxidized low-density lipoprotein (oxLDL) is a key feature of the atheromatosus plaque and
plays a critical role in foam cell formation and perpetuation of inflammatory processes. In …

Oxidized low density lipoproteins: the bridge between atherosclerosis and autoimmunity. Possible implications in accelerated atherosclerosis and for immune …

CF Suciu, M Prete, P Ruscitti, E Favoino… - Autoimmunity …, 2018 - Elsevier
Atherosclerotic vasculopathy is a multifactorial process causing vessels damage and
cardiovascular diseases, the leading causes of death worldwide. Atherosclerotic plaque is …