Long thought of as a bystander in pathophysiological processes, lipid molecules have
emerged as bioactive mediators of cellular activity. Oxidized phospholipids (OxPLs) …

Increasing evidence points to the role of oxidized phospholipids as modulators of
inflammatory processes. These modified phospholipids are derived from lipoproteins or …

Atherosclerosis is a chronic inflammatory disease, resulting from hyperlipidemia and a
complex interplay of many environmental, metabolic, and genetic risk factors. The …

Elevated plasma levels of low-density lipoprotein and generation of oxidized low-density
lipoprotein have been directly associated with the pathogenesis of atherosclerosis, and lipid …

Prolonged or excessive exposure to oxidized phospholipids (OxPLs) generates chronic
inflammation. OxPLs are present in atherosclerotic lesions and can be detected in plasma …

Oxidized phospholipids, such as the products of the oxidation of 1-palmitoyl-2-arachidonoyl-
sn-glycero-3-phosphocholine by nonenzymatic radical attack, are known to be formed in a …

Phospholipid peroxidation products are recognized as important bioactive lipid mediators
playing an active role as modulators in signalling events in inflammation, immunity and …

Over the past decade, there has been intense investigation in trying to understand the
pathological role that oxidized phospholipids play in cardiovascular disease. Phospholipids …

Oxidized low-density lipoprotein (oxLDL) is thought to promote atherosclerosis through
complex inflammatory and immunologic mechanisms that lead to lipid dysregulation and …

Atherosclerosis and ensuing cardiovascular disease (CVD) are major complications of
diabetes type 2. Atherosclerosis is a chronic inflammatory condition involving …